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- W2208764133 abstract "The effects of human amnion epithelial cells (hAECs) on angiogenesis remain controversial. It is yet unknown if the presence of inflammation and/or gestational age of hAEC donors have an impact on angiogenesis. In this study, we examined the differences between term and preterm hAECs on angiogenesis in vitro and in vivo . Conditioned media from term hAECs induced the formation of longer huVEC tubules on Matrigel. Both term and preterm hAECs expressed VEGFA , PDGFB, ANGPT1, and FOXC1 , which significantly increased after TNF α and IFN γ stimulation. In the presence of TNF α and IFN γ , coculture with term hAECs reduced gene transcription of Tie-2 and Foxc1 in huVECs, while coculture with preterm hAECs increased gene transcription of PDGFR α and PDGFR β and reduced gene transcription of FOXC1 in huVECs. In vivo assessment of angiogenesis using vWF immunostaining revealed that hAEC treatment decreased angiogenesis in a bleomycin model of lung fibrosis but increased angiogenesis in a neonatal model of hyperoxia-induced lung injury. In summary, our findings suggested that the impact of hAECs on angiogenesis may be influenced by the presence of inflammation and underlying pathology." @default.
- W2208764133 created "2016-06-24" @default.
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- W2208764133 date "2016-01-01" @default.
- W2208764133 modified "2023-10-14" @default.
- W2208764133 title "Evaluating the Impact of Human Amnion Epithelial Cells on Angiogenesis" @default.
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- W2208764133 doi "https://doi.org/10.1155/2016/4565612" @default.
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