Matches in SemOpenAlex for { <https://semopenalex.org/work/W2208934017> ?p ?o ?g. }
- W2208934017 endingPage "5927" @default.
- W2208934017 startingPage "5912" @default.
- W2208934017 abstract "After spinal cord injury, inflammatory reaction induces the aggregation of astrocytes to form a glial scar that eventually blocks axonal regeneration. Transcription factor CCAAT/enhancer-binding protein delta (C/EBPδ) is a regulatory protein of genes responsive to inflammatory factors, but its role in glial scar formation after spinal cord injury remains unknown. By using a model of moderate spinal cord contusion injury at the mid-thoracic level, we found that C/EBPδ was expressed mostly in the reactive astrocytes bordering the lesion in wild-type mice from 7 days after the injury. C/EBPδ-deficient mice showed reduced glial scar formation, more residual white matter, and better motor function recovery compared with wild-type mice 28 days after the injury. Upon interleukin (IL)-1β stimulation in vitro, the increased expression of C/EBPδ in reactive astrocytes inhibited RhoA expression and, subsequently, the ability of astrocyte migration. However, these reactive astrocytes also produced an increased amount of matrix metalloproteinase-3, which promoted the migration of non-IL-1β-treated, inactive astrocytes. Although the involvement of other non-astroglial C/EBPδ cannot be entirely excluded, our studies suggest that astrocytic C/EBPδ is integral to the inflammatory cascades leading to glial scar formation after spinal cord injury." @default.
- W2208934017 created "2016-06-24" @default.
- W2208934017 creator A5012883843 @default.
- W2208934017 creator A5021734865 @default.
- W2208934017 creator A5041036027 @default.
- W2208934017 creator A5060810511 @default.
- W2208934017 creator A5077631838 @default.
- W2208934017 creator A5080880299 @default.
- W2208934017 creator A5089520944 @default.
- W2208934017 date "2015-10-28" @default.
- W2208934017 modified "2023-10-16" @default.
- W2208934017 title "Astrocytic CCAAT/Enhancer-Binding Protein Delta Contributes to Glial Scar Formation and Impairs Functional Recovery After Spinal Cord Injury" @default.
- W2208934017 cites W1700608000 @default.
- W2208934017 cites W1760881456 @default.
- W2208934017 cites W1864517042 @default.
- W2208934017 cites W1877235802 @default.
- W2208934017 cites W1908112684 @default.
- W2208934017 cites W1929023701 @default.
- W2208934017 cites W1967626391 @default.
- W2208934017 cites W1968375296 @default.
- W2208934017 cites W1969619562 @default.
- W2208934017 cites W1971238455 @default.
- W2208934017 cites W1978748141 @default.
- W2208934017 cites W1980020952 @default.
- W2208934017 cites W1983325630 @default.
- W2208934017 cites W1983712592 @default.
- W2208934017 cites W1984086927 @default.
- W2208934017 cites W1996230045 @default.
- W2208934017 cites W1999271548 @default.
- W2208934017 cites W2004553739 @default.
- W2208934017 cites W2010795766 @default.
- W2208934017 cites W2013144126 @default.
- W2208934017 cites W2015495442 @default.
- W2208934017 cites W2018421371 @default.
- W2208934017 cites W2019610319 @default.
- W2208934017 cites W2019731805 @default.
- W2208934017 cites W2020122922 @default.
- W2208934017 cites W2020850411 @default.
- W2208934017 cites W2026302446 @default.
- W2208934017 cites W2033431263 @default.
- W2208934017 cites W2037711162 @default.
- W2208934017 cites W2052990948 @default.
- W2208934017 cites W2054190000 @default.
- W2208934017 cites W2055466090 @default.
- W2208934017 cites W2063891183 @default.
- W2208934017 cites W2066520425 @default.
- W2208934017 cites W2066651120 @default.
- W2208934017 cites W2069548932 @default.
- W2208934017 cites W2069951758 @default.
- W2208934017 cites W2070916476 @default.
- W2208934017 cites W2083043675 @default.
- W2208934017 cites W2083489746 @default.
- W2208934017 cites W2085424855 @default.
- W2208934017 cites W2089894687 @default.
- W2208934017 cites W2094407932 @default.
- W2208934017 cites W2095263564 @default.
- W2208934017 cites W2101667799 @default.
- W2208934017 cites W2103037576 @default.
- W2208934017 cites W2104968232 @default.
- W2208934017 cites W2115352319 @default.
- W2208934017 cites W2119282745 @default.
- W2208934017 cites W2121784455 @default.
- W2208934017 cites W2121860798 @default.
- W2208934017 cites W2123129865 @default.
- W2208934017 cites W2123922653 @default.
- W2208934017 cites W2124085296 @default.
- W2208934017 cites W2124809007 @default.
- W2208934017 cites W2127338217 @default.
- W2208934017 cites W2128475302 @default.
- W2208934017 cites W2135376726 @default.
- W2208934017 cites W2137005364 @default.
- W2208934017 cites W2159833922 @default.
- W2208934017 cites W2162874382 @default.
- W2208934017 cites W2164814468 @default.
- W2208934017 cites W2412395027 @default.
- W2208934017 cites W3006610610 @default.
- W2208934017 cites W4294309388 @default.
- W2208934017 doi "https://doi.org/10.1007/s12035-015-9486-6" @default.
- W2208934017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5085997" @default.
- W2208934017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26510742" @default.
- W2208934017 hasPublicationYear "2015" @default.
- W2208934017 type Work @default.
- W2208934017 sameAs 2208934017 @default.
- W2208934017 citedByCount "18" @default.
- W2208934017 countsByYear W22089340172017 @default.
- W2208934017 countsByYear W22089340172018 @default.
- W2208934017 countsByYear W22089340172019 @default.
- W2208934017 countsByYear W22089340172020 @default.
- W2208934017 countsByYear W22089340172021 @default.
- W2208934017 countsByYear W22089340172022 @default.
- W2208934017 countsByYear W22089340172023 @default.
- W2208934017 crossrefType "journal-article" @default.
- W2208934017 hasAuthorship W2208934017A5012883843 @default.
- W2208934017 hasAuthorship W2208934017A5021734865 @default.
- W2208934017 hasAuthorship W2208934017A5041036027 @default.
- W2208934017 hasAuthorship W2208934017A5060810511 @default.
- W2208934017 hasAuthorship W2208934017A5077631838 @default.
- W2208934017 hasAuthorship W2208934017A5080880299 @default.