FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2209002685> ?p ?o ?g. }

• W2209002685 endingPage "62" @default.
• W2209002685 startingPage "53" @default.
• W2209002685 abstract "Heteronuclear and homonuclear direct (D) and indirect (J) spin-spin interactions are important sources of structural information about nucleic acids (NAs). The Hamiltonians for the D and J interactions have the same functional form; thus, the experimentally measured apparent spin-spin coupling constant corresponds to a sum of J and D. In biomolecular NMR studies, it is commonly presumed that the dipolar contributions to Js are effectively canceled due to random molecular tumbling. However, in strong magnetic fields, such as those employed for NMR analysis, the tumbling of NA fragments is anisotropic because the inherent magnetic susceptibility of NAs causes an interaction with the external magnetic field. This motional anisotropy is responsible for non-zero D contributions to Js. Here, we calculated the field-induced D contributions to 33 structurally relevant scalar coupling constants as a function of magnetic field strength, temperature and NA fragment size. We identified two classes of Js, namely (1)JCH and (3)JHH couplings, whose quantitative interpretation is notably biased by NA motional anisotropy. For these couplings, the magnetic field-induced dipolar contributions were found to exceed the typical experimental error in J-coupling determinations by a factor of two or more and to produce considerable over- or under-estimations of the J coupling-related torsion angles, especially at magnetic field strengths >12 T and for NA fragments longer than 12 bp. We show that if the non-zero D contributions to J are not properly accounted for, they might cause structural artifacts/bias in NA studies that use solution NMR spectroscopy." @default.
• W2209002685 created "2016-06-24" @default.
• W2209002685 creator A5004795781 @default.
• W2209002685 creator A5030848754 @default.
• W2209002685 creator A5035567220 @default.
• W2209002685 creator A5041174715 @default.
• W2209002685 creator A5046591373 @default.
• W2209002685 creator A5056575702 @default.
• W2209002685 creator A5071916609 @default.
• W2209002685 creator A5076448959 @default.
• W2209002685 date "2015-12-19" @default.
• W2209002685 modified "2023-10-18" @default.
• W2209002685 title "Impact of nucleic acid self-alignment in a strong magnetic field on the interpretation of indirect spin–spin interactions" @default.
• W2209002685 cites W1525311362 @default.
• W2209002685 cites W1560586614 @default.
• W2209002685 cites W1804317820 @default.
• W2209002685 cites W1963727438 @default.
• W2209002685 cites W1969544322 @default.
• W2209002685 cites W1977489331 @default.
• W2209002685 cites W1980722147 @default.
• W2209002685 cites W1989322076 @default.
• W2209002685 cites W1989487251 @default.
• W2209002685 cites W1989904876 @default.
• W2209002685 cites W1994328955 @default.
• W2209002685 cites W1995462823 @default.
• W2209002685 cites W1996668919 @default.
• W2209002685 cites W1998417052 @default.
• W2209002685 cites W2000773276 @default.
• W2209002685 cites W2011896002 @default.
• W2209002685 cites W2014438102 @default.
• W2209002685 cites W2015302653 @default.
• W2209002685 cites W2019327577 @default.
• W2209002685 cites W2022301620 @default.
• W2209002685 cites W2022430620 @default.
• W2209002685 cites W2026022703 @default.
• W2209002685 cites W2030740727 @default.
• W2209002685 cites W2032339090 @default.
• W2209002685 cites W2035693213 @default.
• W2209002685 cites W2039817232 @default.
• W2209002685 cites W2043347092 @default.
• W2209002685 cites W2049296992 @default.
• W2209002685 cites W2052510418 @default.
• W2209002685 cites W2054164390 @default.
• W2209002685 cites W2055055519 @default.
• W2209002685 cites W2057661546 @default.
• W2209002685 cites W2058048068 @default.
• W2209002685 cites W2058363175 @default.
• W2209002685 cites W2060653299 @default.
• W2209002685 cites W2070342290 @default.
• W2209002685 cites W2073486807 @default.
• W2209002685 cites W2084619794 @default.
• W2209002685 cites W2087968879 @default.
• W2209002685 cites W2087972651 @default.
• W2209002685 cites W2090189932 @default.
• W2209002685 cites W2093968495 @default.
• W2209002685 cites W2095474273 @default.
• W2209002685 cites W2102916539 @default.
• W2209002685 cites W2112103709 @default.
• W2209002685 cites W2114296842 @default.
• W2209002685 cites W2123524260 @default.
• W2209002685 cites W2134463889 @default.
• W2209002685 cites W2139544554 @default.
• W2209002685 cites W2143825685 @default.
• W2209002685 cites W2143981217 @default.
• W2209002685 cites W2144525976 @default.
• W2209002685 cites W2146058008 @default.
• W2209002685 cites W2156078935 @default.
• W2209002685 cites W2169655552 @default.
• W2209002685 cites W286775371 @default.
• W2209002685 cites W312456114 @default.
• W2209002685 doi "https://doi.org/10.1007/s10858-015-0005-x" @default.
• W2209002685 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4969947" @default.
• W2209002685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27215413" @default.
• W2209002685 hasPublicationYear "2015" @default.
• W2209002685 type Work @default.
• W2209002685 sameAs 2209002685 @default.
• W2209002685 citedByCount "7" @default.
• W2209002685 countsByYear W22090026852017 @default.
• W2209002685 countsByYear W22090026852018 @default.
• W2209002685 countsByYear W22090026852019 @default.
• W2209002685 countsByYear W22090026852020 @default.
• W2209002685 countsByYear W22090026852021 @default.
• W2209002685 crossrefType "journal-article" @default.
• W2209002685 hasAuthorship W2209002685A5004795781 @default.
• W2209002685 hasAuthorship W2209002685A5030848754 @default.
• W2209002685 hasAuthorship W2209002685A5035567220 @default.
• W2209002685 hasAuthorship W2209002685A5041174715 @default.
• W2209002685 hasAuthorship W2209002685A5046591373 @default.
• W2209002685 hasAuthorship W2209002685A5056575702 @default.
• W2209002685 hasAuthorship W2209002685A5071916609 @default.
• W2209002685 hasAuthorship W2209002685A5076448959 @default.
• W2209002685 hasBestOaLocation W22090026851 @default.
• W2209002685 hasConcept C115260700 @default.
• W2209002685 hasConcept C121332964 @default.
• W2209002685 hasConcept C127413603 @default.
• W2209002685 hasConcept C131584629 @default.
• W2209002685 hasConcept C140463767 @default.
• W2209002685 hasConcept C173523689 @default.

• next