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• W2209016149 abstract "ObjectivePrevious reports suggested that the birth weights of children born from FET were significantly higher from those of naturally conceived children, but those difference disappeared by the age of 18 months. Developmental scores are supposed to be similar between children born from ART and those naturally conceived.The aim of this study is to ascertain any difference in body growth and psychomotor development up to 18 months in children born via assisted reproductive technology (ART) compared with natural conceptions in Japan, a racially homogeneous country.DesignMulticenter retrospective cohort study.Materials and MethodsEight hundred forty-nine singleton children born from fresh embryo transfer (FreET), 1325 from FET, 612 from infertility treatment other than ART (INF) and 542 spontaneously conceived children (SC) were recruited between 1 October 2008 and 30 November 2009. All of the embryo freezing was performed by vitrification. In a voluntary setting, the parents of these children answered a structured mailed questionnaire concerning body growth and developmental status. The precise ART treatment records of each child were matched with data from the Japanese ART register. Developmental status was measured by the parents using the KIDS developmental scoring system.ResultsBirth weights of singleton children conceived by FreET, FET, INF and SC were 3017, 3071, 2975 and 2998 g and after 18 month, 10451, 10461, 10266 and 10356 g, respectively. Although the birth weight of FET singleton babies was significantly heavier than that of NC and INF babies at birth (P < 0.001), none of the treatment modalities (ovarian stimulation, IVF or ICSI) had any relationship with this difference. Those differences disappeared at 18 months of age, after adjusting for sex, BMI at birth and birth order. Congenital malformations were not recognized in 67% at birth, then recognized by 18 months. The development score was significantly superior in children conceived by FreET, FET and INF compared with SC children (P < 0.005).ConclusionsThe birth weights of singleton children born from frozen embryo transfer (FET), which were significantly heavier, became similar at the age of 18 months. Developmental scores were not inferior among the ART children at the age of 18 months, compared with those of naturally conceived children. ObjectivePrevious reports suggested that the birth weights of children born from FET were significantly higher from those of naturally conceived children, but those difference disappeared by the age of 18 months. Developmental scores are supposed to be similar between children born from ART and those naturally conceived.The aim of this study is to ascertain any difference in body growth and psychomotor development up to 18 months in children born via assisted reproductive technology (ART) compared with natural conceptions in Japan, a racially homogeneous country. Previous reports suggested that the birth weights of children born from FET were significantly higher from those of naturally conceived children, but those difference disappeared by the age of 18 months. Developmental scores are supposed to be similar between children born from ART and those naturally conceived.The aim of this study is to ascertain any difference in body growth and psychomotor development up to 18 months in children born via assisted reproductive technology (ART) compared with natural conceptions in Japan, a racially homogeneous country. DesignMulticenter retrospective cohort study. Multicenter retrospective cohort study. Materials and MethodsEight hundred forty-nine singleton children born from fresh embryo transfer (FreET), 1325 from FET, 612 from infertility treatment other than ART (INF) and 542 spontaneously conceived children (SC) were recruited between 1 October 2008 and 30 November 2009. All of the embryo freezing was performed by vitrification. In a voluntary setting, the parents of these children answered a structured mailed questionnaire concerning body growth and developmental status. The precise ART treatment records of each child were matched with data from the Japanese ART register. Developmental status was measured by the parents using the KIDS developmental scoring system. Eight hundred forty-nine singleton children born from fresh embryo transfer (FreET), 1325 from FET, 612 from infertility treatment other than ART (INF) and 542 spontaneously conceived children (SC) were recruited between 1 October 2008 and 30 November 2009. All of the embryo freezing was performed by vitrification. In a voluntary setting, the parents of these children answered a structured mailed questionnaire concerning body growth and developmental status. The precise ART treatment records of each child were matched with data from the Japanese ART register. Developmental status was measured by the parents using the KIDS developmental scoring system. ResultsBirth weights of singleton children conceived by FreET, FET, INF and SC were 3017, 3071, 2975 and 2998 g and after 18 month, 10451, 10461, 10266 and 10356 g, respectively. Although the birth weight of FET singleton babies was significantly heavier than that of NC and INF babies at birth (P < 0.001), none of the treatment modalities (ovarian stimulation, IVF or ICSI) had any relationship with this difference. Those differences disappeared at 18 months of age, after adjusting for sex, BMI at birth and birth order. Congenital malformations were not recognized in 67% at birth, then recognized by 18 months. The development score was significantly superior in children conceived by FreET, FET and INF compared with SC children (P < 0.005). Birth weights of singleton children conceived by FreET, FET, INF and SC were 3017, 3071, 2975 and 2998 g and after 18 month, 10451, 10461, 10266 and 10356 g, respectively. Although the birth weight of FET singleton babies was significantly heavier than that of NC and INF babies at birth (P < 0.001), none of the treatment modalities (ovarian stimulation, IVF or ICSI) had any relationship with this difference. Those differences disappeared at 18 months of age, after adjusting for sex, BMI at birth and birth order. Congenital malformations were not recognized in 67% at birth, then recognized by 18 months. The development score was significantly superior in children conceived by FreET, FET and INF compared with SC children (P < 0.005). ConclusionsThe birth weights of singleton children born from frozen embryo transfer (FET), which were significantly heavier, became similar at the age of 18 months. Developmental scores were not inferior among the ART children at the age of 18 months, compared with those of naturally conceived children. The birth weights of singleton children born from frozen embryo transfer (FET), which were significantly heavier, became similar at the age of 18 months. Developmental scores were not inferior among the ART children at the age of 18 months, compared with those of naturally conceived children." @default.
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• W2209016149 date "2015-09-01" @default.
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• W2209016149 title "Long term prognosis of children born through assisted reproductive technologies in Japan" @default.
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