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- W2209058096 abstract "Introduction: Human periodontitis is the most common infectious disease that results in the destruction of periodontal supporting tissues including the root cementum. Currently cementum regeneration, as a vital event, is considered as a gold standard of successful periodontal tissue reconstruction. Nevertheless, one of the important requirements of cementum reestablishment is the recruitment and differentiation of pre-cementoblasts into functional cementoblasts, which requires effective regulator factors. Recently, Osterix (Osx) is known to be a key transcriptional factor essential for osteogenesis and especially for cementogenesis. Although there are various interesting approaches involving tissue engineering, gene-activated matrix (GAM) is one of the most promising approaches to achieve reliable restoration of the periodontium. The Hypothesis: Based on the recent advances in understanding the mechanisms of Osx in cementum development and formation, we hypothesize that Osx plays a critical role in periodontal regeneration and Osx combined with GAM may be an effective strategy for the regeneration of cementum. Evaluation of the Hypothesis: Osx combined with GAM could pave the way for the development of new tissue engineering procedures and have the potential to play a pivotal role in cementum regeneration, eventually increasing the predictability of periodontal tissue regeneration." @default.
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- W2209058096 date "2015-01-01" @default.
- W2209058096 modified "2023-09-23" @default.
- W2209058096 title "Osterix combined with gene-activated matrix: A potential integrated strategy for achieving cementum regeneration" @default.
- W2209058096 doi "https://doi.org/10.4103/2155-8213.150864" @default.
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