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• W2209181844 startingPage "107" @default.
• W2209181844 abstract "Breast cancer prevention with pharmacologic agents requires that the breast be exposed to an effective drug; systemic exposure is unnecessary, and its harms lead many eligible women to decline preventive therapy. Local transdermal therapy (LTT) to the breast involves the application of active drugs to the breast skin, resulting in high concentrations in the breast but low systemic exposure. It is non-invasive, self-delivered, and not dependent on hepatic metabolism. Existing data on LTT include investigations demonstrating relief of mastalgia with topical 4-hydroxytamoxifen (4-OHT, an active tamoxifen metabolite). Two presurgical window trials in women with invasive breast cancer, and ductal carcinoma in situ (DCIS) demonstrate that LTT decreases proliferation of invasive and non-invasive cancer cells to a similar degree as oral tamoxifen, with low systemic levels, and no effect on coagulation proteins. These data are promising regarding the use of LTT for the primary prevention of breast cancer, and for therapy of DCIS, since systemic exposure is not required for either of these purposes. They also suggest that an LTT approach could be developed for any small, lipophilic molecule with good dermal permeation, thus greatly expanding the menu of drugs that could be tested for breast cancer prevention." @default.
• W2209181844 created "2016-06-24" @default.
• W2209181844 creator A5075214231 @default.
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• W2209181844 date "2016-02-01" @default.
• W2209181844 modified "2023-09-26" @default.
• W2209181844 title "Novel routes for administering chemoprevention: local transdermal therapy to the breasts" @default.
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• W2209181844 cites W1970531647 @default.
• W2209181844 cites W1980469090 @default.
• W2209181844 cites W1981125500 @default.
• W2209181844 cites W1983075194 @default.
• W2209181844 cites W1984305355 @default.
• W2209181844 cites W1984901643 @default.
• W2209181844 cites W1990786325 @default.
• W2209181844 cites W1991118471 @default.
• W2209181844 cites W1998525632 @default.
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• W2209181844 cites W2003726111 @default.
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• W2209181844 cites W2007111202 @default.
• W2209181844 cites W2011995842 @default.
• W2209181844 cites W2012420608 @default.
• W2209181844 cites W2013581172 @default.
• W2209181844 cites W2023461645 @default.
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• W2209181844 cites W2035366757 @default.
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• W2209181844 cites W2067962376 @default.
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• W2209181844 cites W2081313489 @default.
• W2209181844 cites W2082764531 @default.
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• W2209181844 cites W2089082522 @default.
• W2209181844 cites W2090476016 @default.
• W2209181844 cites W2096406493 @default.
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• W2209181844 cites W2107875366 @default.
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• W2209181844 cites W2139434007 @default.
• W2209181844 cites W2144882396 @default.
• W2209181844 cites W2145493691 @default.
• W2209181844 cites W2150953709 @default.
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• W2209181844 cites W2163137304 @default.
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• W2209181844 cites W2169491501 @default.
• W2209181844 cites W2321765359 @default.
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• W2209181844 doi "https://doi.org/10.1053/j.seminoncol.2015.09.003" @default.
• W2209181844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26970129" @default.
• W2209181844 hasPublicationYear "2016" @default.
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