Matches in SemOpenAlex for { <https://semopenalex.org/work/W2209329607> ?p ?o ?g. }
- W2209329607 endingPage "56" @default.
- W2209329607 startingPage "48" @default.
- W2209329607 abstract "Succinylation is a posttranslational modification (PTM) where a succinyl group is added to a Lys (K) residue of a protein molecule. Lysine succinylation plays an important role in orchestrating various biological processes, but it is also associated with some diseases. Therefore, we are challenged by the following problem from both basic research and drug development: given an uncharacterized protein sequence containing many Lys residues, which one of them can be succinylated, and which one cannot? With the avalanche of protein sequences generated in the postgenomic age, the answer to the problem has become even more urgent. Fortunately, the statistical significance experimental data for succinylated sites in proteins have become available very recently, an indispensable prerequisite for developing a computational method to address this problem. By incorporating the sequence-coupling effects into the general pseudo amino acid composition and using KNNC (K-nearest neighbors cleaning) treatment and IHTS (inserting hypothetical training samples) treatment to optimize the training dataset, a predictor called iSuc-PseOpt has been developed. Rigorous cross-validations indicated that it remarkably outperformed the existing method. A user-friendly web-server for iSuc-PseOpt has been established at http://www.jci-bioinfo.cn/iSuc-PseOpt, where users can easily get their desired results without needing to go through the complicated mathematical equations involved." @default.
- W2209329607 created "2016-06-24" @default.
- W2209329607 creator A5015107909 @default.
- W2209329607 creator A5033602780 @default.
- W2209329607 creator A5069962599 @default.
- W2209329607 creator A5083281814 @default.
- W2209329607 creator A5084123261 @default.
- W2209329607 date "2016-03-01" @default.
- W2209329607 modified "2023-10-16" @default.
- W2209329607 title "iSuc-PseOpt: Identifying lysine succinylation sites in proteins by incorporating sequence-coupling effects into pseudo components and optimizing imbalanced training dataset" @default.
- W2209329607 cites W1186776093 @default.
- W2209329607 cites W1494484168 @default.
- W2209329607 cites W1514758940 @default.
- W2209329607 cites W1561712938 @default.
- W2209329607 cites W1612034467 @default.
- W2209329607 cites W1913728360 @default.
- W2209329607 cites W1918744929 @default.
- W2209329607 cites W1943237984 @default.
- W2209329607 cites W1965749072 @default.
- W2209329607 cites W1966991202 @default.
- W2209329607 cites W1968361401 @default.
- W2209329607 cites W1969287319 @default.
- W2209329607 cites W1969899640 @default.
- W2209329607 cites W1971057981 @default.
- W2209329607 cites W1977927254 @default.
- W2209329607 cites W1979648586 @default.
- W2209329607 cites W1981091069 @default.
- W2209329607 cites W1983808106 @default.
- W2209329607 cites W1984148780 @default.
- W2209329607 cites W1984658022 @default.
- W2209329607 cites W1987713050 @default.
- W2209329607 cites W1991141438 @default.
- W2209329607 cites W1995173448 @default.
- W2209329607 cites W1998064689 @default.
- W2209329607 cites W2001168095 @default.
- W2209329607 cites W2004132756 @default.
- W2209329607 cites W2010211703 @default.
- W2209329607 cites W2010219232 @default.
- W2209329607 cites W2010979687 @default.
- W2209329607 cites W2014875362 @default.
- W2209329607 cites W2015452969 @default.
- W2209329607 cites W2018559830 @default.
- W2209329607 cites W2020969907 @default.
- W2209329607 cites W2021573989 @default.
- W2209329607 cites W2022965734 @default.
- W2209329607 cites W2025301291 @default.
- W2209329607 cites W2028161249 @default.
- W2209329607 cites W2028549892 @default.
- W2209329607 cites W2031848873 @default.
- W2209329607 cites W2034070267 @default.
- W2209329607 cites W2037838449 @default.
- W2209329607 cites W2044904175 @default.
- W2209329607 cites W2047187013 @default.
- W2209329607 cites W2049023560 @default.
- W2209329607 cites W2053765706 @default.
- W2209329607 cites W2056108729 @default.
- W2209329607 cites W2059971420 @default.
- W2209329607 cites W2067448387 @default.
- W2209329607 cites W2071834506 @default.
- W2209329607 cites W2073223847 @default.
- W2209329607 cites W2075820422 @default.
- W2209329607 cites W2082247817 @default.
- W2209329607 cites W2082436128 @default.
- W2209329607 cites W2084387914 @default.
- W2209329607 cites W2090561245 @default.
- W2209329607 cites W2091505355 @default.
- W2209329607 cites W2093509030 @default.
- W2209329607 cites W2105014712 @default.
- W2209329607 cites W2109268993 @default.
- W2209329607 cites W2114024619 @default.
- W2209329607 cites W2116062594 @default.
- W2209329607 cites W2118467383 @default.
- W2209329607 cites W2118729365 @default.
- W2209329607 cites W2120026469 @default.
- W2209329607 cites W2121464890 @default.
- W2209329607 cites W2123525093 @default.
- W2209329607 cites W2124266758 @default.
- W2209329607 cites W2132247880 @default.
- W2209329607 cites W2132292391 @default.
- W2209329607 cites W2138045300 @default.
- W2209329607 cites W2143635696 @default.
- W2209329607 cites W2144620643 @default.
- W2209329607 cites W2145957695 @default.
- W2209329607 cites W2148143831 @default.
- W2209329607 cites W2148741118 @default.
- W2209329607 cites W2150047146 @default.
- W2209329607 cites W2158698691 @default.
- W2209329607 cites W2160257187 @default.
- W2209329607 cites W2161621183 @default.
- W2209329607 cites W2167666169 @default.
- W2209329607 cites W2169880855 @default.
- W2209329607 cites W2170747616 @default.
- W2209329607 cites W2172162168 @default.
- W2209329607 cites W2313411748 @default.
- W2209329607 cites W2315928616 @default.
- W2209329607 cites W2340088447 @default.
- W2209329607 cites W2397556949 @default.
- W2209329607 cites W2911964244 @default.