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- W2209331389 abstract "GM-CSF was originally identified as a colony stimulating factor (CSF) because of its ability to induce granulocyte and macrophage populations from precursor cells. Multiple studies have demonstrated that GM-CSF is also an immune-modulatory cytokine, capable of affecting not only the phenotype of myeloid lineage cells, but also T-cell activation through various myeloid intermediaries. This property has been implicated in the sustenance of several autoimmune diseases like arthritis and multiple sclerosis. In contrast, several studies using animal models have shown that GM-CSF is also capable of suppressing many autoimmune diseases such as Crohn's disease, Type-1 diabetes, Myasthenia gravis and experimental autoimmune thyroiditis. Knockout mouse studies have suggested that the role of GM-CSF in maintaining granulocyte and macrophage populations in the physiological steady state is largely redundant. Instead, its immune-modulatory role plays a significant role in the development or resolution of autoimmune diseases. This is mediated either through the differentiation of precursor cells into specialized non-steady state granulocytes, macrophages and dendritic cells, or through the modulation of the phenotype of mature myeloid cells. Thus, outside of myelopoiesis, GM-CSF has a profound role in regulating the immune response and maintaining immunological tolerance." @default.
- W2209331389 created "2016-06-24" @default.
- W2209331389 creator A5004707957 @default.
- W2209331389 creator A5015815835 @default.
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- W2209331389 creator A5046027936 @default.
- W2209331389 creator A5061163803 @default.
- W2209331389 creator A5070953775 @default.
- W2209331389 date "2015-10-01" @default.
- W2209331389 modified "2023-09-30" @default.
- W2209331389 title "GM-CSF: An immune modulatory cytokine that can suppress autoimmunity" @default.
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