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- W2209406738 abstract "Uptake of acetaldehyde in the perfused liver was linear at acetaldehyde concentrations between 0.08 and l. O mM. The intramitochondrial pyridine nucleotide redox state increased as a function of the rate of acetaldehyde uptake. Fructose stimulated acetaldehyde uptake proportionally to the basal rate of acetaldehyde uptake. Concomitantly, fructose accelerated glucose synthesis and oxygen uptake. These results indicate that addition of fructose increased hepatic acetaldehyde metabolism by increasing the availability of NAD+. This is similar to the mechanism described for the stimulation of hepatic ethanol metabolism by fructose (9). Thus, acetaldehyde metabolism by liver is limited, at least in part, by the concentration of acetaldehyde, and by the rate at which pyridine nucleotides are reoxidized." @default.
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- W2209406738 date "1977-01-01" @default.
- W2209406738 modified "2023-10-15" @default.
- W2209406738 title "STIMULATION OF HEPATIC ACETALDEHYDE UPTAKE IN PERFUSED RAT LIVER BY FRUCTOSE" @default.
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- W2209406738 doi "https://doi.org/10.1016/b978-0-12-691403-0.50033-1" @default.
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