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- W2209595530 abstract "Background: The actinomycetic mycetomas, mainly by Nocardia brasiliensis, show prematurely tendency to invade profound tissues, and so the serious prognostic in the dorsal localization that invades the vertebral channel and the spinal cord. Objetive: To demonstrate the blood dissemination and the invasion to organs by Nocardia brasiliensis since footpad mycetoma in Balb/c mice. material and methods: Thirty nine Balb/c mice were inoculated with 0.15 mL of a Nocardia brasiliensis suspension (1 mg/mL) by footpad route. The control animals received the same volume with saline solution. The animals that showed systemic symptoms were dissected and their brain and kidneys were analyzed by haematoxilin-eosin and Ziehl-Neelsen stains. Besides, the cultures in Sabouraud agar to reisolate the microorganism were done. Results: All the animals developed Nocardia brasiliensis mycetoma in footpad, only three mice showed blood dissemination manifestations as granulomatous lesions and numerous fast acid resistant thin bacilli in kidney and brain associated with brain damage without inflammatory reaction in these organs or grain presence. Conclusion: Nocardia brasiliensis is able to disseminate and invade organs by blood since mycetoma in extremities in 7.6% of the cases," @default.
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- W2209595530 date "2008-01-01" @default.
- W2209595530 modified "2023-10-16" @default.
- W2209595530 title "Diseminación hematógena por Nocardia brasiliensis en tres ratones Balb/c a partir de un micetoma en el cojinete plantar" @default.
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