Matches in SemOpenAlex for { <https://semopenalex.org/work/W2209665340> ?p ?o ?g. }
- W2209665340 endingPage "647" @default.
- W2209665340 startingPage "638" @default.
- W2209665340 abstract "IL-25, also named IL-17E, is a distinct member of the IL-17 cytokine family, which can promote and augment T helper type 2 (Th2) responses locally or systemically. Growing evidence from experimental and clinical studies indicates that the expression of IL-25 and its cognate receptor, IL-17RB/RA, is markedly upregulated in asthmatic conditions. It has also been found that IL-25 induces not only typical eosinophilic inflammation and airway hyperresponsiveness (AHR), but also airway remodelling, manifested by goblet cell hyperplasia, subepithelial collagen deposition and angiogenesis. This review will focus on the discovery, cellular origins and targets of IL-25, and try to update current animal and human studies elucidating the roles of IL-25 in asthma. We conclude that although IL-25 is a pleiotropic cytokine, it may only play its dominant role in a certain specific asthmatic endotype, named 'IL-25 high' phenotype. Thus, targeting IL-25 or its receptor might selectively benefit some subgroups with asthma. Furthermore, the major IL-25 producing as well as responsive cells in the changeable milieu of asthma should be assessed in the future." @default.
- W2209665340 created "2016-06-24" @default.
- W2209665340 creator A5015693854 @default.
- W2209665340 creator A5028746034 @default.
- W2209665340 creator A5046597133 @default.
- W2209665340 creator A5089461717 @default.
- W2209665340 date "2015-12-14" @default.
- W2209665340 modified "2023-10-17" @default.
- W2209665340 title "Interleukin (IL)-25: Pleiotropic roles in asthma" @default.
- W2209665340 cites W1543653831 @default.
- W2209665340 cites W1579720523 @default.
- W2209665340 cites W1592394199 @default.
- W2209665340 cites W1805155421 @default.
- W2209665340 cites W1939035518 @default.
- W2209665340 cites W1942668068 @default.
- W2209665340 cites W1949161732 @default.
- W2209665340 cites W1970555542 @default.
- W2209665340 cites W1979360268 @default.
- W2209665340 cites W1979542628 @default.
- W2209665340 cites W1982011202 @default.
- W2209665340 cites W1996426153 @default.
- W2209665340 cites W1997048122 @default.
- W2209665340 cites W2000086986 @default.
- W2209665340 cites W2002629258 @default.
- W2209665340 cites W2007026199 @default.
- W2209665340 cites W2008996473 @default.
- W2209665340 cites W2015025401 @default.
- W2209665340 cites W2017929603 @default.
- W2209665340 cites W2023685287 @default.
- W2209665340 cites W2026669244 @default.
- W2209665340 cites W2027746633 @default.
- W2209665340 cites W2031966431 @default.
- W2209665340 cites W2033289727 @default.
- W2209665340 cites W2035499658 @default.
- W2209665340 cites W2036163316 @default.
- W2209665340 cites W2042470241 @default.
- W2209665340 cites W2043764313 @default.
- W2209665340 cites W2044739547 @default.
- W2209665340 cites W2047882259 @default.
- W2209665340 cites W2050604953 @default.
- W2209665340 cites W2050706371 @default.
- W2209665340 cites W2055509356 @default.
- W2209665340 cites W2058443507 @default.
- W2209665340 cites W2061847435 @default.
- W2209665340 cites W2076512416 @default.
- W2209665340 cites W2077941293 @default.
- W2209665340 cites W2084318811 @default.
- W2209665340 cites W2085187432 @default.
- W2209665340 cites W2086611890 @default.
- W2209665340 cites W2098778820 @default.
- W2209665340 cites W2099733170 @default.
- W2209665340 cites W2104248821 @default.
- W2209665340 cites W2106117449 @default.
- W2209665340 cites W2107195505 @default.
- W2209665340 cites W2107553722 @default.
- W2209665340 cites W2111367218 @default.
- W2209665340 cites W2112970562 @default.
- W2209665340 cites W2114180142 @default.
- W2209665340 cites W2116444479 @default.
- W2209665340 cites W2116553220 @default.
- W2209665340 cites W2116668018 @default.
- W2209665340 cites W2122192920 @default.
- W2209665340 cites W2123829084 @default.
- W2209665340 cites W2125805192 @default.
- W2209665340 cites W2127180104 @default.
- W2209665340 cites W2130847047 @default.
- W2209665340 cites W2132377598 @default.
- W2209665340 cites W2133805178 @default.
- W2209665340 cites W2135645817 @default.
- W2209665340 cites W2139419077 @default.
- W2209665340 cites W2140206763 @default.
- W2209665340 cites W2140686309 @default.
- W2209665340 cites W2143739257 @default.
- W2209665340 cites W2145159953 @default.
- W2209665340 cites W2152222824 @default.
- W2209665340 cites W2154110743 @default.
- W2209665340 cites W2315018741 @default.
- W2209665340 cites W2461747480 @default.
- W2209665340 doi "https://doi.org/10.1111/resp.12707" @default.
- W2209665340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26699081" @default.
- W2209665340 hasPublicationYear "2015" @default.
- W2209665340 type Work @default.
- W2209665340 sameAs 2209665340 @default.
- W2209665340 citedByCount "48" @default.
- W2209665340 countsByYear W22096653402016 @default.
- W2209665340 countsByYear W22096653402017 @default.
- W2209665340 countsByYear W22096653402018 @default.
- W2209665340 countsByYear W22096653402019 @default.
- W2209665340 countsByYear W22096653402020 @default.
- W2209665340 countsByYear W22096653402021 @default.
- W2209665340 countsByYear W22096653402022 @default.
- W2209665340 countsByYear W22096653402023 @default.
- W2209665340 crossrefType "journal-article" @default.
- W2209665340 hasAuthorship W2209665340A5015693854 @default.
- W2209665340 hasAuthorship W2209665340A5028746034 @default.
- W2209665340 hasAuthorship W2209665340A5046597133 @default.
- W2209665340 hasAuthorship W2209665340A5089461717 @default.
- W2209665340 hasBestOaLocation W22096653401 @default.