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- W2209783755 abstract "Dietary advice is the cornerstone in first-line treatment of metabolic diseases. Nutritional interventions directed at these clinical conditions mainly aim to (a) improve insulin resistance by reducing energy-dense macronutrient intake to obtain weight loss and (b) reduce fluctuations in insulin secretion through avoidance of rapidly absorbable carbohydrates. However, even in the majority of motivated patients selected for clinical trials, massive efforts using this approach have failed to achieve lasting efficacy. Less attention has been given to the role of micronutrients in metabolic diseases. Here, we review the evidence that highlights (a) the importance of iron in pancreatic beta-cell function and dysfunction in diabetes and (b) the integrative pathophysiological effects of tissue iron levels in the interactions among the beta cell, gut microbiome, hypothalamus, innate and adaptive immune systems, and insulin-sensitive tissues. We propose that clinical trials are warranted to clarify the impact of dietary or pharmacological iron reduction on the development of metabolic disorders." @default.
- W2209783755 created "2016-06-24" @default.
- W2209783755 creator A5010404114 @default.
- W2209783755 creator A5016370452 @default.
- W2209783755 creator A5022857754 @default.
- W2209783755 creator A5069392374 @default.
- W2209783755 creator A5090660339 @default.
- W2209783755 date "2016-07-17" @default.
- W2209783755 modified "2023-09-27" @default.
- W2209783755 title "Iron Regulation of Pancreatic Beta-Cell Functions and Oxidative Stress" @default.
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