Matches in SemOpenAlex for { <https://semopenalex.org/work/W2209900941> ?p ?o ?g. }
- W2209900941 endingPage "1067" @default.
- W2209900941 startingPage "1059" @default.
- W2209900941 abstract "In this report we evaluated the functions of hypothalamic amylin in vivo and in vitro. Profiling of hypothalamic neurons revealed that islet amyloid polypeptide (Iapp, precursor to amylin) is expressed in neurons in the lateral hypothalamus, arcuate nucleus, medial preoptic area, and elsewhere. Hypothalamic expression of lapp is markedly decreased in ob/ob mice and normalized by exogenous leptin. In slices, amylin and leptin had similar electrophysiologic effects on lateral hypothalamic leptin receptor ObRb-expressing neurons, while the amylin antagonist AC187 inhibited their activity and blunted the effect of leptin. Finally, i.c.v. infusion of AC187 acutely reduced the anorectic effects of leptin. These data show that hypothalamic amylin is transcriptionally regulated by leptin, that it can act directly on ObRb neurons in concert with leptin, and that it regulates feeding. These findings provide a potential mechanism for the increased efficacy of a metreleptin/pramlintide combination therapy for obesity." @default.
- W2209900941 created "2016-06-24" @default.
- W2209900941 creator A5010291066 @default.
- W2209900941 creator A5017144240 @default.
- W2209900941 creator A5052825834 @default.
- W2209900941 creator A5065622211 @default.
- W2209900941 creator A5067088278 @default.
- W2209900941 date "2015-12-01" @default.
- W2209900941 modified "2023-10-12" @default.
- W2209900941 title "Hypothalamic Amylin Acts in Concert with Leptin to Regulate Food Intake" @default.
- W2209900941 cites W1867981554 @default.
- W2209900941 cites W1968709637 @default.
- W2209900941 cites W1970296714 @default.
- W2209900941 cites W1972128036 @default.
- W2209900941 cites W1973368725 @default.
- W2209900941 cites W1974272006 @default.
- W2209900941 cites W1978540530 @default.
- W2209900941 cites W1999851917 @default.
- W2209900941 cites W2003201565 @default.
- W2209900941 cites W2010328324 @default.
- W2209900941 cites W2012618677 @default.
- W2209900941 cites W2012847399 @default.
- W2209900941 cites W2022366514 @default.
- W2209900941 cites W2025522312 @default.
- W2209900941 cites W2026859494 @default.
- W2209900941 cites W2038951352 @default.
- W2209900941 cites W2054815978 @default.
- W2209900941 cites W2070594264 @default.
- W2209900941 cites W2091231206 @default.
- W2209900941 cites W2130315483 @default.
- W2209900941 cites W2138623655 @default.
- W2209900941 cites W2150626351 @default.
- W2209900941 cites W2156162811 @default.
- W2209900941 cites W2171690356 @default.
- W2209900941 cites W2317720845 @default.
- W2209900941 cites W4322696862 @default.
- W2209900941 doi "https://doi.org/10.1016/j.cmet.2015.10.012" @default.
- W2209900941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27166950" @default.
- W2209900941 hasPublicationYear "2015" @default.
- W2209900941 type Work @default.
- W2209900941 sameAs 2209900941 @default.
- W2209900941 citedByCount "81" @default.
- W2209900941 countsByYear W22099009412016 @default.
- W2209900941 countsByYear W22099009412017 @default.
- W2209900941 countsByYear W22099009412018 @default.
- W2209900941 countsByYear W22099009412019 @default.
- W2209900941 countsByYear W22099009412020 @default.
- W2209900941 countsByYear W22099009412021 @default.
- W2209900941 countsByYear W22099009412022 @default.
- W2209900941 countsByYear W22099009412023 @default.
- W2209900941 crossrefType "journal-article" @default.
- W2209900941 hasAuthorship W2209900941A5010291066 @default.
- W2209900941 hasAuthorship W2209900941A5017144240 @default.
- W2209900941 hasAuthorship W2209900941A5052825834 @default.
- W2209900941 hasAuthorship W2209900941A5065622211 @default.
- W2209900941 hasAuthorship W2209900941A5067088278 @default.
- W2209900941 hasBestOaLocation W22099009411 @default.
- W2209900941 hasConcept C126322002 @default.
- W2209900941 hasConcept C134018914 @default.
- W2209900941 hasConcept C14372207 @default.
- W2209900941 hasConcept C165220095 @default.
- W2209900941 hasConcept C185592680 @default.
- W2209900941 hasConcept C2777003273 @default.
- W2209900941 hasConcept C2777369949 @default.
- W2209900941 hasConcept C2778458369 @default.
- W2209900941 hasConcept C2779306644 @default.
- W2209900941 hasConcept C2780613262 @default.
- W2209900941 hasConcept C2780705028 @default.
- W2209900941 hasConcept C3018685816 @default.
- W2209900941 hasConcept C511355011 @default.
- W2209900941 hasConcept C71924100 @default.
- W2209900941 hasConcept C75908981 @default.
- W2209900941 hasConcept C86803240 @default.
- W2209900941 hasConceptScore W2209900941C126322002 @default.
- W2209900941 hasConceptScore W2209900941C134018914 @default.
- W2209900941 hasConceptScore W2209900941C14372207 @default.
- W2209900941 hasConceptScore W2209900941C165220095 @default.
- W2209900941 hasConceptScore W2209900941C185592680 @default.
- W2209900941 hasConceptScore W2209900941C2777003273 @default.
- W2209900941 hasConceptScore W2209900941C2777369949 @default.
- W2209900941 hasConceptScore W2209900941C2778458369 @default.
- W2209900941 hasConceptScore W2209900941C2779306644 @default.
- W2209900941 hasConceptScore W2209900941C2780613262 @default.
- W2209900941 hasConceptScore W2209900941C2780705028 @default.
- W2209900941 hasConceptScore W2209900941C3018685816 @default.
- W2209900941 hasConceptScore W2209900941C511355011 @default.
- W2209900941 hasConceptScore W2209900941C71924100 @default.
- W2209900941 hasConceptScore W2209900941C75908981 @default.
- W2209900941 hasConceptScore W2209900941C86803240 @default.
- W2209900941 hasIssue "6" @default.
- W2209900941 hasLocation W22099009411 @default.
- W2209900941 hasLocation W22099009412 @default.
- W2209900941 hasOpenAccess W2209900941 @default.
- W2209900941 hasPrimaryLocation W22099009411 @default.
- W2209900941 hasRelatedWork W1520413151 @default.
- W2209900941 hasRelatedWork W1555384975 @default.
- W2209900941 hasRelatedWork W1994309438 @default.
- W2209900941 hasRelatedWork W2016261339 @default.