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• W2209993503 abstract "Standard patch-clamp and intracellular recording techniques were used to monitor membrane excitability changes in adult inferior vagal ganglion neurons (nodose ganglion neurons, NGNs) 5 days following section of the vagus nerve (vagotomy). NGNs were maintained in vivo for 5 days following vagotomy, and then in vitro for 2–9 h prior to recording. Vagotomy increased action potential (AP) threshold by over 200% (264 ± 19 pA, mean ± SE, n = 66) compared with control values (81 ± 20 pA, n = 68; P < 0.001). The number of APs evoked by a 3 times threshold 750-ms depolarizing current decreased by >70% (from 8.3 to 2.3 APs, P < 0.001) and the number of APs evoked by a standardized series of (0.1–0.9 nA, 750 ms) depolarizing current steps decreased by over 80% (from 16.9 APs to 2.6 APs, P < 0.001) in vagotomized NGNs. Similar decreases in excitability were observed in vagotomized NGNs in intact ganglia in vitro studied with “sharp” microelectrode techniques. Baseline electrophysiological properties and changes following vagotomy were similar in right and left NGNs. A “sham” vagotomy procedure had no effect on NGN properties at 5 days, indicating that changes were due to severing the vagus nerve itself, not surrounding tissue damage. NGNs isolated after being maintained 17 h in vivo following vagotomy revealed no differences in excitability, suggesting that vagotomy-induced changes occur some time from 1–5 days after injury. Decreased excitability was still observed in NGNs isolated after 20–21 days in vivo following vagotomy. These data indicate that, in contrast to many primary sensory neurons that are thought to become hyperexcitable following section of their axons, NGNs undergo a marked decrease in electrical excitability following vagotomy." @default.
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• W2209993503 date "2001-01-01" @default.
• W2209993503 modified "2023-10-18" @default.
• W2209993503 title "Vagotomy Decreases Excitability in Primary Vagal Afferent Somata" @default.
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• W2209993503 doi "https://doi.org/10.1152/jn.2001.85.1.247" @default.
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