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- W2210020400 endingPage "341" @default.
- W2210020400 startingPage "315" @default.
- W2210020400 abstract "Ruthenium (II) complexes are promising anticancer molecules due its pharmacological properties and selectivity to cells tumor. The aim of this work was to study the cytotoxic activity, and apoptosis induction of two new ruthenium complexes on a human gastric cancer cell line.Two ruthenium(II) complexes were synthesized: [(H2pbbzim)Ru(tpy-Ph-COOCH3)](Cl)2 (Ru-UCN1), and [(tpy)Ru(tpy-Ph-bzH)](Cl)2 (Ru-UCN3), and their anticancer capacity determined by cytotoxic assays, gene expression analysis, caspase activation and confocal microscopy.Ru-UCN3 is more notably cytotoxic than cisplatin in human gastric cancer cells AGS at 24 h, while Ru-UCN1 is more active against gastric cancer cells than cisplatin at 48 h. The complexes induce apoptosis as shown by RT-qPCR, protease activity, and confocal microscopy. Ru-UCN1 induces the overexpression of pro-apoptotic genes at 3 and 6 h, whereas Ru-UCN3 induces overexpression of these genes at 12 and 24 h. Ru-UCN1 treatment shows a strong activation of caspases 3/7 at 24 h, which was not observed for Ru-UCN3 treatment in the same timeframe.Taken together, this data suggests that Ru-UCN1 and to a lesser extent, Ru-UCN3, may be interesting anticancer agents for gastric cancer." @default.
- W2210020400 created "2016-06-24" @default.
- W2210020400 creator A5006577120 @default.
- W2210020400 date "2015-11-01" @default.
- W2210020400 modified "2023-09-24" @default.
- W2210020400 title "Management of gastric cancer: East vs west" @default.
- W2210020400 cites W12636511 @default.
- W2210020400 cites W1787252376 @default.
- W2210020400 cites W1848862702 @default.
- W2210020400 cites W1919607772 @default.
- W2210020400 cites W1937087099 @default.
- W2210020400 cites W1940613095 @default.
- W2210020400 cites W1945173233 @default.
- W2210020400 cites W1966835567 @default.
- W2210020400 cites W1966983288 @default.
- W2210020400 cites W1970031910 @default.
- W2210020400 cites W1970107675 @default.
- W2210020400 cites W1970344904 @default.
- W2210020400 cites W1974957692 @default.
- W2210020400 cites W1975319982 @default.
- W2210020400 cites W1976569511 @default.
- W2210020400 cites W1976651872 @default.
- W2210020400 cites W1978121834 @default.
- W2210020400 cites W1980762985 @default.
- W2210020400 cites W1982559524 @default.
- W2210020400 cites W1987009448 @default.
- W2210020400 cites W1987345047 @default.
- W2210020400 cites W1990756166 @default.
- W2210020400 cites W1992408996 @default.
- W2210020400 cites W1995507937 @default.
- W2210020400 cites W2002748327 @default.
- W2210020400 cites W2004948599 @default.
- W2210020400 cites W2008322008 @default.
- W2210020400 cites W2010681804 @default.
- W2210020400 cites W2011510957 @default.
- W2210020400 cites W2015370358 @default.
- W2210020400 cites W2022459634 @default.
- W2210020400 cites W2024590196 @default.
- W2210020400 cites W2024949026 @default.
- W2210020400 cites W2026986976 @default.
- W2210020400 cites W2027578968 @default.
- W2210020400 cites W2031493965 @default.
- W2210020400 cites W2031962242 @default.
- W2210020400 cites W2034928508 @default.
- W2210020400 cites W2036984377 @default.
- W2210020400 cites W2039470139 @default.
- W2210020400 cites W2040143851 @default.
- W2210020400 cites W2040872961 @default.
- W2210020400 cites W2046379339 @default.
- W2210020400 cites W2049493016 @default.
- W2210020400 cites W2049789380 @default.
- W2210020400 cites W2050506271 @default.
- W2210020400 cites W2053144686 @default.
- W2210020400 cites W2060731557 @default.
- W2210020400 cites W2065887320 @default.
- W2210020400 cites W2068225833 @default.
- W2210020400 cites W2068244356 @default.
- W2210020400 cites W2085118973 @default.
- W2210020400 cites W2086112837 @default.
- W2210020400 cites W2096528973 @default.
- W2210020400 cites W2096858740 @default.
- W2210020400 cites W2097820456 @default.
- W2210020400 cites W2098719201 @default.
- W2210020400 cites W2099433579 @default.
- W2210020400 cites W2099756738 @default.
- W2210020400 cites W2100439220 @default.
- W2210020400 cites W2101979288 @default.
- W2210020400 cites W2102068378 @default.
- W2210020400 cites W2104631255 @default.
- W2210020400 cites W2104709039 @default.
- W2210020400 cites W2104759721 @default.
- W2210020400 cites W2104965946 @default.
- W2210020400 cites W2105423180 @default.
- W2210020400 cites W2108661938 @default.
- W2210020400 cites W2109491042 @default.
- W2210020400 cites W2110263577 @default.
- W2210020400 cites W2111237964 @default.
- W2210020400 cites W2113947048 @default.
- W2210020400 cites W2114043825 @default.
- W2210020400 cites W2114734455 @default.
- W2210020400 cites W2115072149 @default.
- W2210020400 cites W2115610111 @default.
- W2210020400 cites W2117879926 @default.
- W2210020400 cites W2118143634 @default.
- W2210020400 cites W2119359708 @default.
- W2210020400 cites W2119557593 @default.
- W2210020400 cites W2120390507 @default.
- W2210020400 cites W2122380766 @default.
- W2210020400 cites W2122738313 @default.
- W2210020400 cites W2122866527 @default.
- W2210020400 cites W2124051729 @default.
- W2210020400 cites W2125062521 @default.
- W2210020400 cites W2126532720 @default.
- W2210020400 cites W2127773543 @default.
- W2210020400 cites W2127777974 @default.
- W2210020400 cites W2128328462 @default.
- W2210020400 cites W2129787938 @default.
- W2210020400 cites W2130522735 @default.