Matches in SemOpenAlex for { <https://semopenalex.org/work/W2210133089> ?p ?o ?g. }
- W2210133089 endingPage "649" @default.
- W2210133089 startingPage "635" @default.
- W2210133089 abstract "Microglia, innate immune cells of the CNS, sense infection and damage through overlapping receptor sets. Toll‐like receptor (TLR) 4 recognizes bacterial lipopolysaccharide (LPS) and multiple injury‐associated factors. We show that its co‐receptor CD14 serves three non‐redundant functions in microglia. First, it confers an up to 100‐fold higher LPS sensitivity compared to peripheral macrophages to enable efficient proinflammatory cytokine induction. Second, CD14 prevents excessive responses to massive LPS challenges via an interferon β‐mediated feedback. Third, CD14 is mandatory for microglial reactions to tissue damage‐associated signals. In mice, these functions are essential for balanced CNS responses to bacterial infection, traumatic and ischemic injuries, since CD14 deficiency causes either hypo‐ or hyperinflammation, insufficient or exaggerated immune cell recruitment or worsened stroke outcomes. While CD14 orchestrates functions of TLR4 and related immune receptors, it is itself regulated by TLR and non‐TLR systems to thereby fine‐tune microglial damage‐sensing capacity upon infectious and non‐infectious CNS challenges. GLIA 2016;64:635–649." @default.
- W2210133089 created "2016-06-24" @default.
- W2210133089 creator A5000384925 @default.
- W2210133089 creator A5006000088 @default.
- W2210133089 creator A5009018007 @default.
- W2210133089 creator A5016355522 @default.
- W2210133089 creator A5020510395 @default.
- W2210133089 creator A5020557208 @default.
- W2210133089 creator A5021990691 @default.
- W2210133089 creator A5025120711 @default.
- W2210133089 creator A5026280219 @default.
- W2210133089 creator A5027961775 @default.
- W2210133089 creator A5029380319 @default.
- W2210133089 creator A5031245590 @default.
- W2210133089 creator A5032392651 @default.
- W2210133089 creator A5036052976 @default.
- W2210133089 creator A5037361363 @default.
- W2210133089 creator A5039953079 @default.
- W2210133089 creator A5047186499 @default.
- W2210133089 creator A5050127481 @default.
- W2210133089 creator A5050983886 @default.
- W2210133089 creator A5055109212 @default.
- W2210133089 creator A5067404091 @default.
- W2210133089 creator A5069268891 @default.
- W2210133089 creator A5069877730 @default.
- W2210133089 creator A5082924805 @default.
- W2210133089 creator A5085665229 @default.
- W2210133089 creator A5091239692 @default.
- W2210133089 creator A5091573946 @default.
- W2210133089 date "2015-12-18" @default.
- W2210133089 modified "2023-10-18" @default.
- W2210133089 title "CD14 is a key organizer of microglial responses to CNS infection and injury" @default.
- W2210133089 cites W1485304349 @default.
- W2210133089 cites W1515599953 @default.
- W2210133089 cites W1723295332 @default.
- W2210133089 cites W1890591085 @default.
- W2210133089 cites W1918739823 @default.
- W2210133089 cites W1966327575 @default.
- W2210133089 cites W1967912747 @default.
- W2210133089 cites W1968752094 @default.
- W2210133089 cites W1974055405 @default.
- W2210133089 cites W1999286245 @default.
- W2210133089 cites W2001990724 @default.
- W2210133089 cites W2003674452 @default.
- W2210133089 cites W2004608481 @default.
- W2210133089 cites W2019676172 @default.
- W2210133089 cites W2029320721 @default.
- W2210133089 cites W2032227357 @default.
- W2210133089 cites W2038554653 @default.
- W2210133089 cites W2045772297 @default.
- W2210133089 cites W2046413321 @default.
- W2210133089 cites W2052621996 @default.
- W2210133089 cites W2053166138 @default.
- W2210133089 cites W2056778161 @default.
- W2210133089 cites W2058669152 @default.
- W2210133089 cites W2059912147 @default.
- W2210133089 cites W2061769617 @default.
- W2210133089 cites W2066484050 @default.
- W2210133089 cites W2067267561 @default.
- W2210133089 cites W2077995361 @default.
- W2210133089 cites W2082752553 @default.
- W2210133089 cites W2085099489 @default.
- W2210133089 cites W2087032228 @default.
- W2210133089 cites W2111428445 @default.
- W2210133089 cites W2114104545 @default.
- W2210133089 cites W2122031395 @default.
- W2210133089 cites W2133956375 @default.
- W2210133089 cites W2146052295 @default.
- W2210133089 cites W2156734795 @default.
- W2210133089 doi "https://doi.org/10.1002/glia.22955" @default.
- W2210133089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26683584" @default.
- W2210133089 hasPublicationYear "2015" @default.
- W2210133089 type Work @default.
- W2210133089 sameAs 2210133089 @default.
- W2210133089 citedByCount "61" @default.
- W2210133089 countsByYear W22101330892016 @default.
- W2210133089 countsByYear W22101330892017 @default.
- W2210133089 countsByYear W22101330892018 @default.
- W2210133089 countsByYear W22101330892019 @default.
- W2210133089 countsByYear W22101330892020 @default.
- W2210133089 countsByYear W22101330892021 @default.
- W2210133089 countsByYear W22101330892022 @default.
- W2210133089 countsByYear W22101330892023 @default.
- W2210133089 crossrefType "journal-article" @default.
- W2210133089 hasAuthorship W2210133089A5000384925 @default.
- W2210133089 hasAuthorship W2210133089A5006000088 @default.
- W2210133089 hasAuthorship W2210133089A5009018007 @default.
- W2210133089 hasAuthorship W2210133089A5016355522 @default.
- W2210133089 hasAuthorship W2210133089A5020510395 @default.
- W2210133089 hasAuthorship W2210133089A5020557208 @default.
- W2210133089 hasAuthorship W2210133089A5021990691 @default.
- W2210133089 hasAuthorship W2210133089A5025120711 @default.
- W2210133089 hasAuthorship W2210133089A5026280219 @default.
- W2210133089 hasAuthorship W2210133089A5027961775 @default.
- W2210133089 hasAuthorship W2210133089A5029380319 @default.
- W2210133089 hasAuthorship W2210133089A5031245590 @default.
- W2210133089 hasAuthorship W2210133089A5032392651 @default.
- W2210133089 hasAuthorship W2210133089A5036052976 @default.