Matches in SemOpenAlex for { <https://semopenalex.org/work/W2210264879> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2210264879 endingPage "23" @default.
- W2210264879 startingPage "23" @default.
- W2210264879 abstract "23 Background: Circulating tumor cell (CTC) has emerged as a valuable surrogate tumor marker for cancer diagnosis, prognosis, therapy personalization, and drug discovery. To identify CTCs, EpCAM and/or cytokeratin have been commonly used; however, their expression may diminish for subgroups of breast cancers or during epithelial-mesenchymal transition. A unique approach by targeting folate receptor (FR) on CTCs overcomes the limitation. Cancer cells overexpress FR with high affinity (K D =0.1 nM) to internalize high levels of folate for rapid growth. FR is also found upregulated in most cancers, while at very low levels in normal tissues. Methods: A flow cytometry based in-vitro CTC assay kit (OncoIVDx) was developed by IV Diagnostics Inc to specifically enumerate CTCs which overexpress FRs. 20 mL of 9 metastatic breast cancer (MBC) patients' peripheral blood was collected using CellSave tube before and after the treatment in midst of therapy. CTCs were tagged by fluorescently labeled folate conjugate, while leukocytes were counterstained by anti-CD45. To absolutely count the rare CTCs, a fluorescent bead was added serving internal control. Results: Table. Conclusions: No obvious shift in dot plots was found for patients' leucocytes compared to those in normal sample. Tumor size, histologic grade, nodal involvement and lymphovascular invasion (LVI) did not display a significant association with CTC presence, although more positive nodes with identified LVI might indicate an unfavorable increase in CTC counts. CTC presence was found associated with serum marker CA27.29. A score of 30 and less correlated with CTC response to the treatment. Chemotherapy alone or in combination with hormone therapy did not correlate with the change in CTC counts after treatment, except for hormone therapy alone. Unfavorable progression of cancers could be predicated for the patients with approximately 25 and more CTCs. We would like to thank NIH/NCI for SBIR phase I grant (1R43CA13789301A1). [Table: see text]" @default.
- W2210264879 created "2016-06-24" @default.
- W2210264879 creator A5000721562 @default.
- W2210264879 creator A5010964059 @default.
- W2210264879 creator A5017624531 @default.
- W2210264879 creator A5033060435 @default.
- W2210264879 creator A5061126015 @default.
- W2210264879 creator A5080645855 @default.
- W2210264879 creator A5089141937 @default.
- W2210264879 creator A5090914252 @default.
- W2210264879 date "2011-09-20" @default.
- W2210264879 modified "2023-10-18" @default.
- W2210264879 title "Metastatic breast cancer detection and therapy monitoring using folate-targeting flow cytometry." @default.
- W2210264879 doi "https://doi.org/10.1200/jco.2011.29.27_suppl.23" @default.
- W2210264879 hasPublicationYear "2011" @default.
- W2210264879 type Work @default.
- W2210264879 sameAs 2210264879 @default.
- W2210264879 citedByCount "1" @default.
- W2210264879 countsByYear W22102648792013 @default.
- W2210264879 crossrefType "journal-article" @default.
- W2210264879 hasAuthorship W2210264879A5000721562 @default.
- W2210264879 hasAuthorship W2210264879A5010964059 @default.
- W2210264879 hasAuthorship W2210264879A5017624531 @default.
- W2210264879 hasAuthorship W2210264879A5033060435 @default.
- W2210264879 hasAuthorship W2210264879A5061126015 @default.
- W2210264879 hasAuthorship W2210264879A5080645855 @default.
- W2210264879 hasAuthorship W2210264879A5089141937 @default.
- W2210264879 hasAuthorship W2210264879A5090914252 @default.
- W2210264879 hasConcept C121608353 @default.
- W2210264879 hasConcept C126322002 @default.
- W2210264879 hasConcept C142724271 @default.
- W2210264879 hasConcept C143998085 @default.
- W2210264879 hasConcept C203014093 @default.
- W2210264879 hasConcept C204232928 @default.
- W2210264879 hasConcept C2775930923 @default.
- W2210264879 hasConcept C2778740770 @default.
- W2210264879 hasConcept C2779012181 @default.
- W2210264879 hasConcept C2779013556 @default.
- W2210264879 hasConcept C502942594 @default.
- W2210264879 hasConcept C530470458 @default.
- W2210264879 hasConcept C553184892 @default.
- W2210264879 hasConcept C61238886 @default.
- W2210264879 hasConcept C71924100 @default.
- W2210264879 hasConceptScore W2210264879C121608353 @default.
- W2210264879 hasConceptScore W2210264879C126322002 @default.
- W2210264879 hasConceptScore W2210264879C142724271 @default.
- W2210264879 hasConceptScore W2210264879C143998085 @default.
- W2210264879 hasConceptScore W2210264879C203014093 @default.
- W2210264879 hasConceptScore W2210264879C204232928 @default.
- W2210264879 hasConceptScore W2210264879C2775930923 @default.
- W2210264879 hasConceptScore W2210264879C2778740770 @default.
- W2210264879 hasConceptScore W2210264879C2779012181 @default.
- W2210264879 hasConceptScore W2210264879C2779013556 @default.
- W2210264879 hasConceptScore W2210264879C502942594 @default.
- W2210264879 hasConceptScore W2210264879C530470458 @default.
- W2210264879 hasConceptScore W2210264879C553184892 @default.
- W2210264879 hasConceptScore W2210264879C61238886 @default.
- W2210264879 hasConceptScore W2210264879C71924100 @default.
- W2210264879 hasIssue "27_suppl" @default.
- W2210264879 hasLocation W22102648791 @default.
- W2210264879 hasOpenAccess W2210264879 @default.
- W2210264879 hasPrimaryLocation W22102648791 @default.
- W2210264879 hasRelatedWork W2006173697 @default.
- W2210264879 hasRelatedWork W2018859222 @default.
- W2210264879 hasRelatedWork W2086048147 @default.
- W2210264879 hasRelatedWork W2395906155 @default.
- W2210264879 hasRelatedWork W2549802237 @default.
- W2210264879 hasRelatedWork W2806005235 @default.
- W2210264879 hasRelatedWork W2892287597 @default.
- W2210264879 hasRelatedWork W2979892935 @default.
- W2210264879 hasRelatedWork W73860091 @default.
- W2210264879 hasRelatedWork W2006001742 @default.
- W2210264879 hasVolume "29" @default.
- W2210264879 isParatext "false" @default.
- W2210264879 isRetracted "false" @default.
- W2210264879 magId "2210264879" @default.
- W2210264879 workType "article" @default.