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- W2210672989 endingPage "1048" @default.
- W2210672989 startingPage "1038" @default.
- W2210672989 abstract "Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent and represents a growing challenge in terms of prevention and treatment. Despite its high prevalence, only a small minority of affected patients develops inflammation and subsequently fibrosis and chronic liver disease, while most of them only exhibit simple steatosis. In this context, the full understanding of the mechanisms underlying the development of NAFLD and non-alcoholic steatohepatitis (NASH) is of extreme importance; despite advances in this field, knowledge on the pathogenesis of NAFLD is still incomplete. The ‘two-hit’ hypothesis is now obsolete, as it is inadequate to explain the several molecular and metabolic changes that take place in NAFLD. The “multiple hit” hypothesis considers multiple insults acting together on genetically predisposed subjects to induce NAFLD and provides a more accurate explanation of NAFLD pathogenesis. Such hits include insulin resistance, hormones secreted from the adipose tissue, nutritional factors, gut microbiota and genetic and epigenetic factors. In this article, we review the factors that form this hypothesis." @default.
- W2210672989 created "2016-06-24" @default.
- W2210672989 creator A5009873146 @default.
- W2210672989 creator A5067022693 @default.
- W2210672989 creator A5070306424 @default.
- W2210672989 date "2016-08-01" @default.
- W2210672989 modified "2023-10-14" @default.
- W2210672989 title "The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)" @default.
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