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• W2210954273 endingPage "1062" @default.
• W2210954273 startingPage "1057" @default.
• W2210954273 abstract "We report a pair of identical twins with concordant acute lymphoblastic leukemia (ALL). Unusually, their diagnoses were spaced 9 years apart at ages 5 and 14. Leukemic cells in both twins had aTEL-AML1 rearrangement, which was characterized at the DNA level by an adaptation of a long distance polymerase chain reaction (PCR) method. The genomic fusion sequence was identical in the two leukemias, indicative of a single cell origin in one fetus, in utero. At the time twin 1 was diagnosed (aged 5 years), the bone marrow of twin 2 was hematologically normal. However, retrospective scrutiny of the DNA from an archived slide with clonotypic TEL-AML1 primers showed that the presumptive preleukemic clone was present and disseminated 9 years before a clinical diagnosis. These data provide novel insight into the natural history of childhood leukemia and suggest that consequent to a prenatal initiation of a leukemic clone, most probably by TEL-AML fusion itself, the latency of ALL can be both extremely variable and protracted. This, in turn, is likely to reflect the timing of critical secondary events." @default.
• W2210954273 created "2016-06-24" @default.
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• W2210954273 date "1999-08-01" @default.
• W2210954273 modified "2023-10-11" @default.
• W2210954273 title "Protracted and Variable Latency of Acute Lymphoblastic Leukemia AfterTEL-AML1 Gene Fusion In Utero" @default.
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• W2210954273 doi "https://doi.org/10.1182/blood.v94.3.1057.415k10_1057_1062" @default.
• W2210954273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10419898" @default.
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