FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2211149802> ?p ?o ?g. }

• W2211149802 endingPage "676" @default.
• W2211149802 startingPage "663" @default.
• W2211149802 abstract "Combination treatment through simultaneous delivery of DNA and anticancer drugs with nanoparticles has been demonstrated to be an elegant and efficient approach for cancer therapy. Herein, we employed a combination therapy for eliminating both the tumor cells and intratumoral neovascular network based on the nanoplatform we designed. Pigment epithelium-derived factor (PEDF) gene, a powerful antiangiogenic agent, and the clinically widely used chemotherapy agent paclitaxel (PTX) were simultaneously encapsulated in the same nanoparticle by a modified double-emulsion solvent evaporation method. The dual-drug-loaded nanoparticles (D/P-NPs) exhibited a uniform spherical morphology and released PTX and PEDF gene in a sustained manner. D/P-NPs showed an enhanced antitumor effect on C26 and A549 cells and a stronger inhibitory activity on proliferation of HUVECs. Moreover, D/P-NPs could dramatically elevate the PEDF expression levels in both C26 and A549 cells in comparison with PEDF gene loaded nanoparticles and significantly promote the cellular uptake of PTX. Additionally, microtubules were stabilized and G2/M phase arrest along with a higher subG1 cell population was induced by D/P-NPs in contrast to PTX or PTX loaded nanoparticles. Besides, D/P-NPs showed sustained release of PTX and PEDF gene in tumors as well as long-term gene expression. A significantly improved anticancer effect was also demonstrated in a C26 subcutaneous tumor model using this combinational therapy. D/P-NPs could sharply reduce the microvessel density and significantly promoted tumor cell apoptosis in vivo. More importantly, the in vivo distribution, serological and biochemical analysis, and H&E staining revealed that D/P-NPs had no obvious toxicity. Our study suggested that this novel polymeric nanomedicine had great potential for improving the therapeutic efficacy of combined gene/chemotherapy of cancer." @default.
• W2211149802 created "2016-06-24" @default.
• W2211149802 creator A5001838036 @default.
• W2211149802 creator A5012767886 @default.
• W2211149802 creator A5013077143 @default.
• W2211149802 creator A5016029838 @default.
• W2211149802 creator A5027596703 @default.
• W2211149802 creator A5037458498 @default.
• W2211149802 creator A5040059979 @default.
• W2211149802 creator A5043748613 @default.
• W2211149802 creator A5048505746 @default.
• W2211149802 creator A5049579227 @default.
• W2211149802 creator A5067387552 @default.
• W2211149802 creator A5069567112 @default.
• W2211149802 creator A5079465456 @default.
• W2211149802 creator A5087149945 @default.
• W2211149802 date "2016-01-06" @default.
• W2211149802 modified "2023-10-09" @default.
• W2211149802 title "Polymeric Nanomedicine for Combined Gene/Chemotherapy Elicits Enhanced Tumor Suppression" @default.
• W2211149802 cites W1452895818 @default.
• W2211149802 cites W1978932462 @default.
• W2211149802 cites W1991521906 @default.
• W2211149802 cites W1997627303 @default.
• W2211149802 cites W2000079001 @default.
• W2211149802 cites W2007329636 @default.
• W2211149802 cites W2010179884 @default.
• W2211149802 cites W2010731545 @default.
• W2211149802 cites W2018936822 @default.
• W2211149802 cites W2019661450 @default.
• W2211149802 cites W2021202934 @default.
• W2211149802 cites W2026712777 @default.
• W2211149802 cites W2032517146 @default.
• W2211149802 cites W2033905916 @default.
• W2211149802 cites W2034288807 @default.
• W2211149802 cites W2044558227 @default.
• W2211149802 cites W2049970665 @default.
• W2211149802 cites W2050732886 @default.
• W2211149802 cites W2053649039 @default.
• W2211149802 cites W2055494875 @default.
• W2211149802 cites W2059518503 @default.
• W2211149802 cites W2059862524 @default.
• W2211149802 cites W2068500052 @default.
• W2211149802 cites W2082174953 @default.
• W2211149802 cites W2086690729 @default.
• W2211149802 cites W2103539208 @default.
• W2211149802 cites W2105478944 @default.
• W2211149802 cites W2108845411 @default.
• W2211149802 cites W2149164490 @default.
• W2211149802 cites W2157603347 @default.
• W2211149802 cites W2158787062 @default.
• W2211149802 cites W2163130919 @default.
• W2211149802 cites W2316625236 @default.
• W2211149802 cites W2319074136 @default.
• W2211149802 cites W2325335768 @default.
• W2211149802 doi "https://doi.org/10.1021/acs.molpharmaceut.5b00922" @default.
• W2211149802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26695934" @default.
• W2211149802 hasPublicationYear "2016" @default.
• W2211149802 type Work @default.
• W2211149802 sameAs 2211149802 @default.
• W2211149802 citedByCount "22" @default.
• W2211149802 countsByYear W22111498022016 @default.
• W2211149802 countsByYear W22111498022017 @default.
• W2211149802 countsByYear W22111498022018 @default.
• W2211149802 countsByYear W22111498022019 @default.
• W2211149802 countsByYear W22111498022020 @default.
• W2211149802 countsByYear W22111498022021 @default.
• W2211149802 countsByYear W22111498022022 @default.
• W2211149802 crossrefType "journal-article" @default.
• W2211149802 hasAuthorship W2211149802A5001838036 @default.
• W2211149802 hasAuthorship W2211149802A5012767886 @default.
• W2211149802 hasAuthorship W2211149802A5013077143 @default.
• W2211149802 hasAuthorship W2211149802A5016029838 @default.
• W2211149802 hasAuthorship W2211149802A5027596703 @default.
• W2211149802 hasAuthorship W2211149802A5037458498 @default.
• W2211149802 hasAuthorship W2211149802A5040059979 @default.
• W2211149802 hasAuthorship W2211149802A5043748613 @default.
• W2211149802 hasAuthorship W2211149802A5048505746 @default.
• W2211149802 hasAuthorship W2211149802A5049579227 @default.
• W2211149802 hasAuthorship W2211149802A5067387552 @default.
• W2211149802 hasAuthorship W2211149802A5069567112 @default.
• W2211149802 hasAuthorship W2211149802A5079465456 @default.
• W2211149802 hasAuthorship W2211149802A5087149945 @default.
• W2211149802 hasConcept C104317684 @default.
• W2211149802 hasConcept C111599444 @default.
• W2211149802 hasConcept C121608353 @default.
• W2211149802 hasConcept C126322002 @default.
• W2211149802 hasConcept C135983454 @default.
• W2211149802 hasConcept C150903083 @default.
• W2211149802 hasConcept C185592680 @default.
• W2211149802 hasConcept C190283241 @default.
• W2211149802 hasConcept C207001950 @default.
• W2211149802 hasConcept C2777292972 @default.
• W2211149802 hasConcept C2780394083 @default.
• W2211149802 hasConcept C2908647359 @default.
• W2211149802 hasConcept C502942594 @default.
• W2211149802 hasConcept C52237779 @default.
• W2211149802 hasConcept C55493867 @default.
• W2211149802 hasConcept C71924100 @default.

• next