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- W2211203676 abstract "Background:Even though oxidative stress has been reported to be associated with the development of oral cavity cancer, there is little evidence to show whether patients with more clinical severity suffer from more oxidative stress.Aim and Objectives:We would like to find out the coexistence of the increasing oxidative stress and the clinical severity of patients with oral cavity cancer.Materials and Methods:We launched this study to assess changes of the oxidant statuses, including malondialdehyde (MDA), the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GRx) and glutathione status, including reduced glutathione (GSH) and oxidized glutathione (GSSG), in patients with oral cavity cancer at various clinical stages. Blood samples of 116 male biospy-proven and untreated patients with oral cavity cancer at various clinical stages (from stage Ⅰ to stage Ⅳ) and 122 male healthy controls were obtained.Results:The levels of GSH, GSSG, and total GSH were significantly decreased in the patients in comparison with those of the controls. Conversely, MDA levels and GSH/GSSG were significantly increased. Additionally, MDA, the activities of SOD, and GRx were significantly elevated in the patients, while the activity of GPx was reversed. There were significant changes in the aforementioned parameters in the linear contract test from stage Ⅰ to stage Ⅳ.Conclusions:This study reveals that patients with oral cavity cancer suffered from excessive oxidative stress, which was consistent with other previous studies; moreover, oxidative stress will aggravate as the disease progresses." @default.
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- W2211203676 date "2010-06-01" @default.
- W2211203676 modified "2023-09-26" @default.
- W2211203676 title "Coexistence of the Increasing Oxidative Stress and the Clinical Severity of Patients with Oral Cavity Cancer" @default.
- W2211203676 doi "https://doi.org/10.7096/tjtsps.201006.0104" @default.
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