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• W2211322853 endingPage "172" @default.
• W2211322853 startingPage "147" @default.
• W2211322853 abstract "Coronary heart disease (CHD) is the leading cause of morbidity and mortality in most developed nations and atherosclerotic cardiovascular disease accounts for approximately one-half of all deaths due to CHD. Dyslipidaemias, which include various combinations of hypercholesterolaemia, hypertriglyceridaemia and hypoalphalipoproteinaemia, are major risk factors for atherosclerotic CHD. Current therapy largely treats hypercholesterolaemia, as reflected in the sales of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors (HMGR-Is, statins) which account for a worldwide market share of 88%. The fibrates, which account for 9% of worldwide market share, effectively treat hypertriglyceridaemia but have inconsistent effects on hypercholesterolaemia and hypoalphalipoproteinaemia. Niacin, although an effective treatment for dyslipidaemias, suffers from a poor side-effect profile and therefore poor compliance. Moreover, niacin is not recommended for diabetics, a population in which atherosclerotic cardiovascular disease due largely to dyslipidaemia is the most common cause of death. Although additional strategies to reduce hypercholesterolaemia are still under pursuit (e.g., cholesterol absorption inhibitors, acyl-CoA:cholesterol acyltransferase [ACAT] inhibitors, squalene synthetase [SQS] inhibitors), attention has shifted to therapeutic strategies that affect hypertriglyceridaemia and/or hypoalphalipoproteinaemia in addition to hypercholesterolaemia (e.g., very low-density lipoprotein [VLDL] assembly/secretion inhibitors, thyromimetics, oestrogen agonists, peroxisome proliferator activated receptor [PPAR] activators, cholesterol ester transfer protein [CETP] inhibitors, apolipoprotein A1 [apoA1] production stimulators, lipoprotein lipase [LPL] activators) and these strategies are being aggressively pursued. The status of current efforts in these emerging therapeutic areas is described below." @default.
• W2211322853 created "2016-06-24" @default.
• W2211322853 creator A5047036867 @default.
• W2211322853 creator A5053723666 @default.
• W2211322853 date "1998-06-01" @default.
• W2211322853 modified "2023-10-03" @default.
• W2211322853 title "Modulators of dyslipidaemia" @default.
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