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• W2211393669 abstract "Research Article1 December 1991free access Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation. J.M. Clements J.M. Clements British Bio-technology Ltd, Oxford, UK. Search for more papers by this author L.J. Bawden L.J. Bawden British Bio-technology Ltd, Oxford, UK. Search for more papers by this author R.E. Bloxidge R.E. Bloxidge British Bio-technology Ltd, Oxford, UK. Search for more papers by this author G. Catlin G. Catlin British Bio-technology Ltd, Oxford, UK. Search for more papers by this author A.L. Cook A.L. Cook British Bio-technology Ltd, Oxford, UK. Search for more papers by this author S. Craig S. Craig British Bio-technology Ltd, Oxford, UK. Search for more papers by this author A.H. Drummond A.H. Drummond British Bio-technology Ltd, Oxford, UK. Search for more papers by this author R.M. Edwards R.M. Edwards British Bio-technology Ltd, Oxford, UK. Search for more papers by this author A. Fallon A. Fallon British Bio-technology Ltd, Oxford, UK. Search for more papers by this author D.R. Green D.R. Green British Bio-technology Ltd, Oxford, UK. Search for more papers by this author J.M. Clements J.M. Clements British Bio-technology Ltd, Oxford, UK. Search for more papers by this author L.J. Bawden L.J. Bawden British Bio-technology Ltd, Oxford, UK. Search for more papers by this author R.E. Bloxidge R.E. Bloxidge British Bio-technology Ltd, Oxford, UK. Search for more papers by this author G. Catlin G. Catlin British Bio-technology Ltd, Oxford, UK. Search for more papers by this author A.L. Cook A.L. Cook British Bio-technology Ltd, Oxford, UK. Search for more papers by this author S. Craig S. Craig British Bio-technology Ltd, Oxford, UK. Search for more papers by this author A.H. Drummond A.H. Drummond British Bio-technology Ltd, Oxford, UK. Search for more papers by this author R.M. Edwards R.M. Edwards British Bio-technology Ltd, Oxford, UK. Search for more papers by this author A. Fallon A. Fallon British Bio-technology Ltd, Oxford, UK. Search for more papers by this author D.R. Green D.R. Green British Bio-technology Ltd, Oxford, UK. Search for more papers by this author Author Information J.M. Clements1, L.J. Bawden1, R.E. Bloxidge1, G. Catlin1, A.L. Cook1, S. Craig1, A.H. Drummond1, R.M. Edwards1, A. Fallon1 and D.R. Green1 1British Bio-technology Ltd, Oxford, UK. The EMBO Journal (1991)10:4113-4120https://doi.org/10.1002/j.1460-2075.1991.tb04988.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info PDGF may be involved in the pathogenesis of a variety of disorders including atherosclerosis and certain types of cancer. There is currently little understanding of the molecular structure of PDGF and of the critical amino acid residues involved in receptor binding and cell activation. Two such PDGF-B chain residues, arginine 27 and isoleucine 30, have been identified by a site-directed mutagenesis programme. Substitutions in these positions can lead to PDGF mutants defective in both receptor affinity and cell activation as judged by displacement of [125I]PDGF-BB, mitogenic assay and inositol lipid turnover. Circular dichroism and fluorescence spectroscopy show that such mutations do not disrupt the structure of PDGF. Previous ArticleNext Article Volume 10Issue 131 December 1991In this issue RelatedDetailsLoading ..." @default.
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• W2211393669 title "Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation." @default.
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