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- W2211406503 abstract "Precise targeting of genetic lesions alone has been insufficient to extend brain tumor patient survival. Brain cancer cells are diverse in their genetic, metabolic and microenvironmental compositions, accounting for their phenotypic heterogeneity and disparate responses to therapy. These factors converge at the level of the epigenome, representing a unified node that can be disrupted by pharmacologic inhibition. Aberrant epigenomes define many childhood and adult brain cancers, as demonstrated by widespread changes to DNA methylation patterns, redistribution of histone marks and disruption of chromatin structure. In this Review, we describe the convergence of genetic, metabolic and microenvironmental factors on mechanisms of epigenetic deregulation in brain cancer. We discuss how aberrant epigenetic pathways identified in brain tumors affect cell identity, cell state and neoplastic transformation, as well as addressing the potential to exploit these alterations as new therapeutic strategies for the treatment of brain cancer." @default.
- W2211406503 created "2016-06-24" @default.
- W2211406503 creator A5010033363 @default.
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- W2211406503 creator A5021296578 @default.
- W2211406503 creator A5022310517 @default.
- W2211406503 creator A5044388176 @default.
- W2211406503 date "2015-12-29" @default.
- W2211406503 modified "2023-10-02" @default.
- W2211406503 title "An epigenetic gateway to brain tumor cell identity" @default.
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