FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2211814408> ?p ?o ?g. }

• W2211814408 endingPage "e0144848" @default.
• W2211814408 startingPage "e0144848" @default.
• W2211814408 abstract "Neuronal death in Parkinson's disease (PD) is often preceded by axodendritic tree retraction and loss of neuronal functionality. The presence of non-functional but live neurons opens therapeutic possibilities to recover functionality before clinical symptoms develop. Considering that iron accumulation and oxidative damage are conditions commonly found in PD, we tested the possible neuritogenic effects of iron chelators and antioxidant agents. We used three commercial chelators: DFO, deferiprone and 2.2'-dypyridyl, and three 8-hydroxyquinoline-based iron chelators: M30, 7MH and 7DH, and we evaluated their effects in vitro using a mesencephalic cell culture treated with the Parkinsonian toxin MPP+ and in vivo using the MPTP mouse model. All chelators tested promoted the emergence of new tyrosine hydroxylase (TH)-positive processes, increased axodendritic tree length and protected cells against lipoperoxidation. Chelator treatment resulted in the generation of processes containing the presynaptic marker synaptophysin. The antioxidants N-acetylcysteine and dymetylthiourea also enhanced axodendritic tree recovery in vitro, an indication that reducing oxidative tone fosters neuritogenesis in MPP+-damaged neurons. Oral administration to mice of the M30 chelator for 14 days after MPTP treatment resulted in increased TH- and GIRK2-positive nigra cells and nigrostriatal fibers. Our results support a role for oral iron chelators as good candidates for the early treatment of PD, at stages of the disease where there is axodendritic tree retraction without neuronal death." @default.
• W2211814408 created "2016-06-24" @default.
• W2211814408 creator A5001958070 @default.
• W2211814408 creator A5011854092 @default.
• W2211814408 creator A5014238545 @default.
• W2211814408 creator A5015587496 @default.
• W2211814408 creator A5021699800 @default.
• W2211814408 creator A5042538989 @default.
• W2211814408 creator A5045840806 @default.
• W2211814408 creator A5046496720 @default.
• W2211814408 creator A5051168857 @default.
• W2211814408 creator A5065691519 @default.
• W2211814408 creator A5086076059 @default.
• W2211814408 date "2015-12-14" @default.
• W2211814408 modified "2023-10-06" @default.
• W2211814408 title "Iron Chelators and Antioxidants Regenerate Neuritic Tree and Nigrostriatal Fibers of MPP+/MPTP-Lesioned Dopaminergic Neurons" @default.
• W2211814408 cites W1495047607 @default.
• W2211814408 cites W1510439895 @default.
• W2211814408 cites W1574691536 @default.
• W2211814408 cites W1603624051 @default.
• W2211814408 cites W1730655823 @default.
• W2211814408 cites W1902785172 @default.
• W2211814408 cites W1934800228 @default.
• W2211814408 cites W1965147820 @default.
• W2211814408 cites W1967186030 @default.
• W2211814408 cites W1973050879 @default.
• W2211814408 cites W1974672164 @default.
• W2211814408 cites W1979019820 @default.
• W2211814408 cites W1989405078 @default.
• W2211814408 cites W1994325079 @default.
• W2211814408 cites W1999372252 @default.
• W2211814408 cites W2002572432 @default.
• W2211814408 cites W2004628001 @default.
• W2211814408 cites W2005447847 @default.
• W2211814408 cites W2007304845 @default.
• W2211814408 cites W2020427805 @default.
• W2211814408 cites W2022993728 @default.
• W2211814408 cites W2023974334 @default.
• W2211814408 cites W2029873665 @default.
• W2211814408 cites W2029919931 @default.
• W2211814408 cites W2032907114 @default.
• W2211814408 cites W2034218459 @default.
• W2211814408 cites W2049800884 @default.
• W2211814408 cites W2066701380 @default.
• W2211814408 cites W2069550409 @default.
• W2211814408 cites W2081273853 @default.
• W2211814408 cites W2081389808 @default.
• W2211814408 cites W2082610615 @default.
• W2211814408 cites W2083065734 @default.
• W2211814408 cites W2089953140 @default.
• W2211814408 cites W2095378987 @default.
• W2211814408 cites W2099676980 @default.
• W2211814408 cites W2115958127 @default.
• W2211814408 cites W2116664772 @default.
• W2211814408 cites W2117373936 @default.
• W2211814408 cites W2123249770 @default.
• W2211814408 cites W2127914798 @default.
• W2211814408 cites W2132652745 @default.
• W2211814408 cites W2137617601 @default.
• W2211814408 cites W2139414585 @default.
• W2211814408 cites W2142632602 @default.
• W2211814408 cites W2152301501 @default.
• W2211814408 cites W2157974947 @default.
• W2211814408 cites W2169958158 @default.
• W2211814408 cites W2321410278 @default.
• W2211814408 cites W36288087 @default.
• W2211814408 cites W391900960 @default.
• W2211814408 doi "https://doi.org/10.1371/journal.pone.0144848" @default.
• W2211814408 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4684383" @default.
• W2211814408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26658949" @default.
• W2211814408 hasPublicationYear "2015" @default.
• W2211814408 type Work @default.
• W2211814408 sameAs 2211814408 @default.
• W2211814408 citedByCount "18" @default.
• W2211814408 countsByYear W22118144082016 @default.
• W2211814408 countsByYear W22118144082018 @default.
• W2211814408 countsByYear W22118144082019 @default.
• W2211814408 countsByYear W22118144082020 @default.
• W2211814408 countsByYear W22118144082021 @default.
• W2211814408 countsByYear W22118144082022 @default.
• W2211814408 crossrefType "journal-article" @default.
• W2211814408 hasAuthorship W2211814408A5001958070 @default.
• W2211814408 hasAuthorship W2211814408A5011854092 @default.
• W2211814408 hasAuthorship W2211814408A5014238545 @default.
• W2211814408 hasAuthorship W2211814408A5015587496 @default.
• W2211814408 hasAuthorship W2211814408A5021699800 @default.
• W2211814408 hasAuthorship W2211814408A5042538989 @default.
• W2211814408 hasAuthorship W2211814408A5045840806 @default.
• W2211814408 hasAuthorship W2211814408A5046496720 @default.
• W2211814408 hasAuthorship W2211814408A5051168857 @default.
• W2211814408 hasAuthorship W2211814408A5065691519 @default.
• W2211814408 hasAuthorship W2211814408A5086076059 @default.
• W2211814408 hasBestOaLocation W22118144081 @default.
• W2211814408 hasConcept C126322002 @default.
• W2211814408 hasConcept C137183658 @default.
• W2211814408 hasConcept C159167319 @default.
• W2211814408 hasConcept C169760540 @default.
• W2211814408 hasConcept C185592680 @default.

• next