Matches in SemOpenAlex for { <https://semopenalex.org/work/W2212007995> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2212007995 endingPage "76" @default.
- W2212007995 startingPage "70" @default.
- W2212007995 abstract "1. When [U-(14)C]methylcyclohexane is fed to rabbits (dose 2-2.5m-moles/kg. body wt.), 65% of the radioactivity is excreted in the urine as metabolites, 0.5% appears in the faeces and about 15% in the expired air, some 4-5% remaining in the body in about 60hr. after dosing. The 15% of the dose appearing in the expired air consists of unchanged methylcyclohexane (10%) and (14)CO(2) (5%). The low output of (14)CO(2) shows that reactions leading to complete oxidation of methylcyclohexane are of minor importance. 2. The main metabolite found in the urine was the glucuronide of trans-4-methylcyclohexanol which was isolated. Seven methylcyclohexanols were found in the urine as conjugated glucuronides. The amounts of these were determined by isotope dilution to be as follows: cis-2-, 0.6%; trans-2-, 1.2%; cis-3-, 11.5%; trans-3-, 10.5%; cis-4-, 2.4%; trans-4-methylcyclohexanol, 14.7%, cyclohexylmethanol, 0.3%. No 1-methylcyclohexanol was found. There was evidence also that a small amount (approx. 1%) of the hydrocarbon aromatized to benzoic acid, probably via cyclohexylmethanol and cyclohexane-carboxylic acid. 3. The pattern of hydroxylation and the various amounts of the isomers found suggest that the hydroxylation in vivo of methylcyclohexane is dependent on steric factors in the molecule, hydroxylation occurring to the greatest extent at the carbon atom furthest away from the methyl group." @default.
- W2212007995 created "2016-06-24" @default.
- W2212007995 creator A5028033968 @default.
- W2212007995 creator A5053275054 @default.
- W2212007995 creator A5087685376 @default.
- W2212007995 date "1965-04-01" @default.
- W2212007995 modified "2023-10-16" @default.
- W2212007995 title "THE METABOLISM OF METHYLCYCLOHEXANE" @default.
- W2212007995 cites W1591839376 @default.
- W2212007995 cites W2224615721 @default.
- W2212007995 cites W2235212652 @default.
- W2212007995 cites W2263214734 @default.
- W2212007995 cites W2336452359 @default.
- W2212007995 cites W2339615941 @default.
- W2212007995 cites W2395933687 @default.
- W2212007995 cites W40121397 @default.
- W2212007995 doi "https://doi.org/10.1042/bj0950070" @default.
- W2212007995 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1215178" @default.
- W2212007995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14333569" @default.
- W2212007995 hasPublicationYear "1965" @default.
- W2212007995 type Work @default.
- W2212007995 sameAs 2212007995 @default.
- W2212007995 citedByCount "34" @default.
- W2212007995 countsByYear W22120079952015 @default.
- W2212007995 countsByYear W22120079952018 @default.
- W2212007995 countsByYear W22120079952019 @default.
- W2212007995 crossrefType "journal-article" @default.
- W2212007995 hasAuthorship W2212007995A5028033968 @default.
- W2212007995 hasAuthorship W2212007995A5053275054 @default.
- W2212007995 hasAuthorship W2212007995A5087685376 @default.
- W2212007995 hasBestOaLocation W22120079952 @default.
- W2212007995 hasConcept C155647269 @default.
- W2212007995 hasConcept C178790620 @default.
- W2212007995 hasConcept C181199279 @default.
- W2212007995 hasConcept C185592680 @default.
- W2212007995 hasConcept C2776504022 @default.
- W2212007995 hasConcept C2777477808 @default.
- W2212007995 hasConcept C2778142098 @default.
- W2212007995 hasConcept C2781109383 @default.
- W2212007995 hasConcept C55493867 @default.
- W2212007995 hasConceptScore W2212007995C155647269 @default.
- W2212007995 hasConceptScore W2212007995C178790620 @default.
- W2212007995 hasConceptScore W2212007995C181199279 @default.
- W2212007995 hasConceptScore W2212007995C185592680 @default.
- W2212007995 hasConceptScore W2212007995C2776504022 @default.
- W2212007995 hasConceptScore W2212007995C2777477808 @default.
- W2212007995 hasConceptScore W2212007995C2778142098 @default.
- W2212007995 hasConceptScore W2212007995C2781109383 @default.
- W2212007995 hasConceptScore W2212007995C55493867 @default.
- W2212007995 hasIssue "1" @default.
- W2212007995 hasLocation W22120079951 @default.
- W2212007995 hasLocation W22120079952 @default.
- W2212007995 hasLocation W22120079953 @default.
- W2212007995 hasLocation W22120079954 @default.
- W2212007995 hasOpenAccess W2212007995 @default.
- W2212007995 hasPrimaryLocation W22120079951 @default.
- W2212007995 hasRelatedWork W1965566291 @default.
- W2212007995 hasRelatedWork W1993173413 @default.
- W2212007995 hasRelatedWork W2052493351 @default.
- W2212007995 hasRelatedWork W2148387412 @default.
- W2212007995 hasRelatedWork W2404432230 @default.
- W2212007995 hasRelatedWork W2435284767 @default.
- W2212007995 hasRelatedWork W2560223734 @default.
- W2212007995 hasRelatedWork W2949270372 @default.
- W2212007995 hasRelatedWork W2952323845 @default.
- W2212007995 hasRelatedWork W2953257216 @default.
- W2212007995 hasVolume "95" @default.
- W2212007995 isParatext "false" @default.
- W2212007995 isRetracted "false" @default.
- W2212007995 magId "2212007995" @default.
- W2212007995 workType "article" @default.