Matches in SemOpenAlex for { <https://semopenalex.org/work/W2212023510> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2212023510 endingPage "2017" @default.
- W2212023510 startingPage "2017" @default.
- W2212023510 abstract "2017 Objectives CMRO2 quantification using 15O-O2 PET requires separate cerebral blood flow (CBF) and volume (CBV) measurements and arterial catheterization to determine whole blood and plasma input functions. We develop a theoretical framework for CMRO2 estimation by combining kinetic models used for PET and MRI to examine the feasibility of a novel single step PET/MR. Methods A multi-compartment kinetic model is used to examine the effects of various physiologic parameters and sources of variability on CMRO2 estimation. CBF, CBV, and dural venous sinus oxygen saturation (arterial spine labeling, dynamic susceptibility contrast, and T2-relaxation-under-spin-tagging) are combined with dynamic PET data and blood sampling to estimate regional CMRO2. Accuracy was determined by systematically or randomly varying the underlying physiological parameters and simulating PET and MR responses. A detailed model of blood oxygenation dependent (BOLD) signal was used to simulate task specific modulation of brain activity. Results Our theoretical analysis suggests that systematic modality specific differences in CBF, CBV, and OEF measurements cancel out in CMRO2 estimation. The recirculating labeled water and arterial input function can be estimated from venous blood sampling combined with noninvasive measures (dural sinus venous saturation, total CBF, and arterial and venous blood pool tracer activity), eliminating the need for arterial catheterization. A calibrated BOLD methodology is described for measuring task specific modulations of CMRO2 and neurovascular coupling, as well as quantifying the venous blood volume fraction. Conclusions CMRO2 is an important physiologic quantity. However, measuring CMRO2 using PET requires complicated steps not practical in most clinical settings. No reliable technique for measuring absolute CMRO2 using MRI exists. The advent of PET/MR makes it possible to measure CMRO2 more efficiently, less invasively, and with markedly less radiation than PET alone. Research Support UCSD radiology & center for fMRI" @default.
- W2212023510 created "2016-06-24" @default.
- W2212023510 creator A5034705511 @default.
- W2212023510 creator A5041500174 @default.
- W2212023510 creator A5058113326 @default.
- W2212023510 date "2014-05-01" @default.
- W2212023510 modified "2023-09-26" @default.
- W2212023510 title "A theoretical framework for quantification of cerebral metabolic rate of oxygen (CMRO2) using PET/MR" @default.
- W2212023510 hasPublicationYear "2014" @default.
- W2212023510 type Work @default.
- W2212023510 sameAs 2212023510 @default.
- W2212023510 citedByCount "0" @default.
- W2212023510 crossrefType "journal-article" @default.
- W2212023510 hasAuthorship W2212023510A5034705511 @default.
- W2212023510 hasAuthorship W2212023510A5041500174 @default.
- W2212023510 hasAuthorship W2212023510A5058113326 @default.
- W2212023510 hasConcept C126322002 @default.
- W2212023510 hasConcept C126838900 @default.
- W2212023510 hasConcept C157767197 @default.
- W2212023510 hasConcept C158846371 @default.
- W2212023510 hasConcept C164705383 @default.
- W2212023510 hasConcept C2775842073 @default.
- W2212023510 hasConcept C2776663645 @default.
- W2212023510 hasConcept C2779537118 @default.
- W2212023510 hasConcept C2780868729 @default.
- W2212023510 hasConcept C2982720008 @default.
- W2212023510 hasConcept C2988731192 @default.
- W2212023510 hasConcept C2989005 @default.
- W2212023510 hasConcept C37557685 @default.
- W2212023510 hasConcept C43044207 @default.
- W2212023510 hasConcept C71924100 @default.
- W2212023510 hasConceptScore W2212023510C126322002 @default.
- W2212023510 hasConceptScore W2212023510C126838900 @default.
- W2212023510 hasConceptScore W2212023510C157767197 @default.
- W2212023510 hasConceptScore W2212023510C158846371 @default.
- W2212023510 hasConceptScore W2212023510C164705383 @default.
- W2212023510 hasConceptScore W2212023510C2775842073 @default.
- W2212023510 hasConceptScore W2212023510C2776663645 @default.
- W2212023510 hasConceptScore W2212023510C2779537118 @default.
- W2212023510 hasConceptScore W2212023510C2780868729 @default.
- W2212023510 hasConceptScore W2212023510C2982720008 @default.
- W2212023510 hasConceptScore W2212023510C2988731192 @default.
- W2212023510 hasConceptScore W2212023510C2989005 @default.
- W2212023510 hasConceptScore W2212023510C37557685 @default.
- W2212023510 hasConceptScore W2212023510C43044207 @default.
- W2212023510 hasConceptScore W2212023510C71924100 @default.
- W2212023510 hasLocation W22120235101 @default.
- W2212023510 hasOpenAccess W2212023510 @default.
- W2212023510 hasPrimaryLocation W22120235101 @default.
- W2212023510 hasRelatedWork W1507677395 @default.
- W2212023510 hasRelatedWork W1977230663 @default.
- W2212023510 hasRelatedWork W2004195348 @default.
- W2212023510 hasRelatedWork W2015554928 @default.
- W2212023510 hasRelatedWork W2018376941 @default.
- W2212023510 hasRelatedWork W2027345658 @default.
- W2212023510 hasRelatedWork W2038590120 @default.
- W2212023510 hasRelatedWork W2046469028 @default.
- W2212023510 hasRelatedWork W2066012982 @default.
- W2212023510 hasRelatedWork W2116530611 @default.
- W2212023510 hasRelatedWork W2146903472 @default.
- W2212023510 hasRelatedWork W2220119916 @default.
- W2212023510 hasRelatedWork W242234746 @default.
- W2212023510 hasRelatedWork W2531068913 @default.
- W2212023510 hasRelatedWork W2565619309 @default.
- W2212023510 hasRelatedWork W2762935335 @default.
- W2212023510 hasRelatedWork W2983184954 @default.
- W2212023510 hasRelatedWork W3132748731 @default.
- W2212023510 hasRelatedWork W3158359590 @default.
- W2212023510 hasRelatedWork W4407057 @default.
- W2212023510 hasVolume "55" @default.
- W2212023510 isParatext "false" @default.
- W2212023510 isRetracted "false" @default.
- W2212023510 magId "2212023510" @default.
- W2212023510 workType "article" @default.