Matches in SemOpenAlex for { <https://semopenalex.org/work/W2212110557> ?p ?o ?g. }
- W2212110557 endingPage "e0138665" @default.
- W2212110557 startingPage "e0138665" @default.
- W2212110557 abstract "Antibody levels wane rapidly after Meningococcal serogroup C conjugate (MenCC) vaccination in young children, rendering the need for an adolescent booster dose. It is not clear whether circulating memory B cells are associated with persistence of MenC-specific antibody levels.Measurement of MenC-specific IgG and IgA memory B cells and levels of serum and salivary MenC-specific IgG and IgA in healthy 10-, 12- and 15-year-olds prior to and one month and one year after a MenCC booster vaccination. All participants had received a primary MenCC vaccination nine years earlier.The number of circulating MenC-specific IgG memory B cells prior to booster was low and not predictive for MenC-specific IgG responses in serum or saliva post-booster, whereas the number of MenC-specific IgA memory B cells pre-booster positively correlated with MenC-specific IgA levels in saliva post-booster (R = 0.5, P<0.05). The booster induced a clear increase in the number of MenC-specific IgG and IgA memory B cells. The number of MenC-PS-specific IgG memory B cells at 1 month post-booster was highest in the 12-year-olds. The number of MenC-specific memory B cells at one month post-booster showed no correlation with the rate of MenC-specific antibody decay throughout the first year post-booster.Circulating MenC-specific IgA memory B cells correlate with IgA responses in saliva, whereas circulating MenC-specific IgG memory B cells are not predictive for MenC-specific IgG responses in serum or saliva. Our results are suggestive for age-dependent differences in pre-existing memory against MenC." @default.
- W2212110557 created "2016-06-24" @default.
- W2212110557 creator A5020796910 @default.
- W2212110557 creator A5042910491 @default.
- W2212110557 creator A5048500830 @default.
- W2212110557 creator A5057380077 @default.
- W2212110557 creator A5065777909 @default.
- W2212110557 creator A5072531063 @default.
- W2212110557 creator A5090351414 @default.
- W2212110557 date "2015-10-12" @default.
- W2212110557 modified "2023-09-23" @default.
- W2212110557 title "Different Dynamics for IgG and IgA Memory B Cells in Adolescents following a Meningococcal Serogroup C Tetanus Toxoid Conjugate Booster Vaccination Nine Years after Priming: A Role for Priming Age?" @default.
- W2212110557 cites W1933668405 @default.
- W2212110557 cites W1971473212 @default.
- W2212110557 cites W2009056434 @default.
- W2212110557 cites W2009852881 @default.
- W2212110557 cites W2019896390 @default.
- W2212110557 cites W2029016985 @default.
- W2212110557 cites W2031433025 @default.
- W2212110557 cites W2034748893 @default.
- W2212110557 cites W2049628926 @default.
- W2212110557 cites W2052139850 @default.
- W2212110557 cites W2068368401 @default.
- W2212110557 cites W2074610853 @default.
- W2212110557 cites W2086909360 @default.
- W2212110557 cites W2088685963 @default.
- W2212110557 cites W2091356778 @default.
- W2212110557 cites W2092452128 @default.
- W2212110557 cites W2102748782 @default.
- W2212110557 cites W2116458521 @default.
- W2212110557 cites W2116995839 @default.
- W2212110557 cites W2118963825 @default.
- W2212110557 cites W2118976076 @default.
- W2212110557 cites W2128715866 @default.
- W2212110557 cites W2137053577 @default.
- W2212110557 cites W2137586712 @default.
- W2212110557 cites W2141563230 @default.
- W2212110557 cites W2156961356 @default.
- W2212110557 cites W2161397634 @default.
- W2212110557 cites W2171028861 @default.
- W2212110557 cites W2171280186 @default.
- W2212110557 cites W785487230 @default.
- W2212110557 doi "https://doi.org/10.1371/journal.pone.0138665" @default.
- W2212110557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4601787" @default.
- W2212110557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26458006" @default.
- W2212110557 hasPublicationYear "2015" @default.
- W2212110557 type Work @default.
- W2212110557 sameAs 2212110557 @default.
- W2212110557 citedByCount "3" @default.
- W2212110557 countsByYear W22121105572017 @default.
- W2212110557 countsByYear W22121105572019 @default.
- W2212110557 countsByYear W22121105572020 @default.
- W2212110557 crossrefType "journal-article" @default.
- W2212110557 hasAuthorship W2212110557A5020796910 @default.
- W2212110557 hasAuthorship W2212110557A5042910491 @default.
- W2212110557 hasAuthorship W2212110557A5048500830 @default.
- W2212110557 hasAuthorship W2212110557A5057380077 @default.
- W2212110557 hasAuthorship W2212110557A5065777909 @default.
- W2212110557 hasAuthorship W2212110557A5072531063 @default.
- W2212110557 hasAuthorship W2212110557A5090351414 @default.
- W2212110557 hasBestOaLocation W22121105571 @default.
- W2212110557 hasConcept C100701293 @default.
- W2212110557 hasConcept C126322002 @default.
- W2212110557 hasConcept C159654299 @default.
- W2212110557 hasConcept C203014093 @default.
- W2212110557 hasConcept C22070199 @default.
- W2212110557 hasConcept C2777351567 @default.
- W2212110557 hasConcept C2778453870 @default.
- W2212110557 hasConcept C2779359726 @default.
- W2212110557 hasConcept C2779583294 @default.
- W2212110557 hasConcept C2779841045 @default.
- W2212110557 hasConcept C2780454893 @default.
- W2212110557 hasConcept C2780801004 @default.
- W2212110557 hasConcept C2780898057 @default.
- W2212110557 hasConcept C504460877 @default.
- W2212110557 hasConcept C59822182 @default.
- W2212110557 hasConcept C71924100 @default.
- W2212110557 hasConcept C81444415 @default.
- W2212110557 hasConcept C86803240 @default.
- W2212110557 hasConceptScore W2212110557C100701293 @default.
- W2212110557 hasConceptScore W2212110557C126322002 @default.
- W2212110557 hasConceptScore W2212110557C159654299 @default.
- W2212110557 hasConceptScore W2212110557C203014093 @default.
- W2212110557 hasConceptScore W2212110557C22070199 @default.
- W2212110557 hasConceptScore W2212110557C2777351567 @default.
- W2212110557 hasConceptScore W2212110557C2778453870 @default.
- W2212110557 hasConceptScore W2212110557C2779359726 @default.
- W2212110557 hasConceptScore W2212110557C2779583294 @default.
- W2212110557 hasConceptScore W2212110557C2779841045 @default.
- W2212110557 hasConceptScore W2212110557C2780454893 @default.
- W2212110557 hasConceptScore W2212110557C2780801004 @default.
- W2212110557 hasConceptScore W2212110557C2780898057 @default.
- W2212110557 hasConceptScore W2212110557C504460877 @default.
- W2212110557 hasConceptScore W2212110557C59822182 @default.
- W2212110557 hasConceptScore W2212110557C71924100 @default.
- W2212110557 hasConceptScore W2212110557C81444415 @default.
- W2212110557 hasConceptScore W2212110557C86803240 @default.
- W2212110557 hasIssue "10" @default.