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- W2212166543 abstract "Endocrine disorders are substantial contributors to neonatal morbidity and mortality and, of these, congenital hypothyroidism (CH) is the most common (Kumar et al. 2009). CH is a common and preventable cause of mental retardation with an incidence of approximately 1 in 2,350 live births (Hinton et al. 2010). In Iowa, the Iowa Neonatal Metabolic Screening program (INMSP) uses thyroid stimulating hormone (TSH) to screen for CH at birth. However, TSH is highly variable among healthy newborns as well as adults, leading to false positive results in some cases. Previous studies have observed that adult TSH variability is under strong genetic regulation with estimated heritability of up to 65% (Panicker et al. 2008). Additionally, there have been multiple studies examining genetic factors associated with adult TSH levels. TSH heritability has never been estimated in the neonatal period and we aimed to determine the heritability in neonates and compare it to heritability estimates in adults. We examined 381 twin pairs obtained from the INMSP. Heritability was estimated using multilevel mixed-effects linear regression adjusting for factors affecting TSH levels; gestational age, gender, weight and age at time of sample collection. We estimated neonatal TSH heritability to be 58% with a P-value of 2x10, which mirrors adult heritability estimates, and provides direct evidence for a strong genetic contribution to TSH variability at birth. We next examined genetic factors that may contribute to the observed heritability. Genetic contribution to TSH variation has been studied extensively in adults, but not in neonates. We genotyped a population of Iowa neonates; term (n=827) and preterm (n=815), for 45 single nucleotide polymorphisms (SNPs) that we selected based on reported genetic associations with adult TSH levels from the literature, as well as other candidate genes. TSH values were obtained from the INMSP. Analysis of variance was performed to identify genetic associations with TSH concentrations. The strongest" @default.
- W2212166543 created "2016-06-24" @default.
- W2212166543 creator A5088141729 @default.
- W2212166543 date "2018-11-29" @default.
- W2212166543 modified "2023-10-11" @default.
- W2212166543 title "Investigating the genetics Of thyroid stimulating hormone in newborns" @default.
- W2212166543 cites W1963756943 @default.
- W2212166543 cites W1966650173 @default.
- W2212166543 cites W1968712897 @default.
- W2212166543 cites W1968747399 @default.
- W2212166543 cites W1970964327 @default.
- W2212166543 cites W1971977144 @default.
- W2212166543 cites W1972994957 @default.
- W2212166543 cites W1973923444 @default.
- W2212166543 cites W1974211516 @default.
- W2212166543 cites W1974825591 @default.
- W2212166543 cites W1975086606 @default.
- W2212166543 cites W1976062879 @default.
- W2212166543 cites W1976624715 @default.
- W2212166543 cites W1978560444 @default.
- W2212166543 cites W1980991473 @default.
- W2212166543 cites W1982494061 @default.
- W2212166543 cites W1985490660 @default.
- W2212166543 cites W1985756920 @default.
- W2212166543 cites W1986134516 @default.
- W2212166543 cites W1988822924 @default.
- W2212166543 cites W1990871387 @default.
- W2212166543 cites W1992049566 @default.
- W2212166543 cites W1994967480 @default.
- W2212166543 cites W1995092017 @default.
- W2212166543 cites W1999060428 @default.
- W2212166543 cites W1999298535 @default.
- W2212166543 cites W2006141598 @default.
- W2212166543 cites W2009399942 @default.
- W2212166543 cites W2016104730 @default.
- W2212166543 cites W2016190735 @default.
- W2212166543 cites W2017771330 @default.
- W2212166543 cites W2021114539 @default.
- W2212166543 cites W2021975487 @default.
- W2212166543 cites W2023587452 @default.
- W2212166543 cites W2027942918 @default.
- W2212166543 cites W2029912876 @default.
- W2212166543 cites W2031597554 @default.
- W2212166543 cites W2041425692 @default.
- W2212166543 cites W2047547074 @default.
- W2212166543 cites W2049142663 @default.
- W2212166543 cites W2050362839 @default.
- W2212166543 cites W2055139820 @default.
- W2212166543 cites W2055468921 @default.
- W2212166543 cites W2056297572 @default.
- W2212166543 cites W2057520583 @default.
- W2212166543 cites W2057854693 @default.
- W2212166543 cites W2060516267 @default.
- W2212166543 cites W2061195919 @default.
- W2212166543 cites W2063801510 @default.
- W2212166543 cites W2066752187 @default.
- W2212166543 cites W2067365866 @default.
- W2212166543 cites W2068483634 @default.
- W2212166543 cites W2070359414 @default.
- W2212166543 cites W2076411581 @default.
- W2212166543 cites W2080817589 @default.
- W2212166543 cites W2083172698 @default.
- W2212166543 cites W2084237827 @default.
- W2212166543 cites W2088287802 @default.
- W2212166543 cites W2090136933 @default.
- W2212166543 cites W2093253556 @default.
- W2212166543 cites W2094923832 @default.
- W2212166543 cites W2097650598 @default.
- W2212166543 cites W2098641028 @default.
- W2212166543 cites W2099783126 @default.
- W2212166543 cites W2102878215 @default.
- W2212166543 cites W2105885585 @default.
- W2212166543 cites W2106258006 @default.
- W2212166543 cites W2107915455 @default.
- W2212166543 cites W2112100215 @default.
- W2212166543 cites W2112964323 @default.
- W2212166543 cites W2113004875 @default.
- W2212166543 cites W2113371850 @default.
- W2212166543 cites W2115103964 @default.
- W2212166543 cites W2115317383 @default.
- W2212166543 cites W2116729076 @default.
- W2212166543 cites W2118978221 @default.
- W2212166543 cites W2119015742 @default.
- W2212166543 cites W2119998094 @default.
- W2212166543 cites W2120806571 @default.
- W2212166543 cites W2122596290 @default.
- W2212166543 cites W2122770938 @default.
- W2212166543 cites W2123452207 @default.
- W2212166543 cites W2125712542 @default.
- W2212166543 cites W2128016314 @default.
- W2212166543 cites W2131533686 @default.
- W2212166543 cites W2136078375 @default.
- W2212166543 cites W2138275857 @default.
- W2212166543 cites W2138691653 @default.
- W2212166543 cites W2141034208 @default.
- W2212166543 cites W2146734921 @default.
- W2212166543 cites W2147558065 @default.
- W2212166543 cites W2148844750 @default.
- W2212166543 cites W2150054282 @default.
- W2212166543 cites W2150825072 @default.