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• W2212178620 endingPage "e1005266" @default.
• W2212178620 startingPage "e1005266" @default.
• W2212178620 abstract "Genetic recombination shapes the diversity of RNA viruses, including enteroviruses (EVs), which frequently have mosaic genomes. Pathogenic circulating vaccine-derived poliovirus (cVDPV) genomes consist of mutated vaccine poliovirus (PV) sequences encoding capsid proteins, and sequences encoding nonstructural proteins derived from other species’ C EVs, including certain coxsackieviruses A (CV-A) in particular. Many cVDPV genomes also have an exogenous 5’ untranslated region (5’ UTR). This region is involved in virulence and includes the cloverleaf (CL) and the internal ribosomal entry site, which play major roles in replication and the initiation of translation, respectively. We investigated the plasticity of the PV genome in terms of recombination in the 5’ UTR, by developing an experimental model involving the rescue of a bipartite PV/CV-A cVDPV genome rendered defective by mutations in the CL, following the co-transfection of cells with 5’ UTR RNAs from each of the four human EV species (EV-A to -D). The defective cVDPV was rescued by recombination with 5’ UTR sequences from the four EV species. Homologous and nonhomologous recombinants with large deletions or insertions in three hotspots were isolated, revealing a striking plasticity of the 5’ UTR. By contrast to the recombination of the cVDPV with the 5’ UTR of group II (EV-A and -B), which can decrease viral replication and virulence, recombination with the 5’ UTRs of group I (EV-C and -D) appeared to be evolutionarily neutral or associated with a gain in fitness. This study illustrates how the genomes of positive-strand RNA viruses can evolve into mosaic recombinant genomes through intra- or inter-species modular genetic exchanges, favoring the emergence of new recombinant lineages." @default.
• W2212178620 created "2016-06-24" @default.
• W2212178620 creator A5005772049 @default.
• W2212178620 creator A5026211265 @default.
• W2212178620 creator A5035628443 @default.
• W2212178620 creator A5081363543 @default.
• W2212178620 creator A5089806133 @default.
• W2212178620 date "2015-11-12" @default.
• W2212178620 modified "2023-10-02" @default.
• W2212178620 title "Evolution and Emergence of Enteroviruses through Intra- and Inter-species Recombination: Plasticity and Phenotypic Impact of Modular Genetic Exchanges in the 5’ Untranslated Region" @default.
• W2212178620 cites W143205737 @default.
• W2212178620 cites W1529709430 @default.
• W2212178620 cites W1559631147 @default.
• W2212178620 cites W1571685587 @default.
• W2212178620 cites W1641036754 @default.
• W2212178620 cites W1671980812 @default.
• W2212178620 cites W1691537760 @default.
• W2212178620 cites W1803835389 @default.
• W2212178620 cites W1840105038 @default.
• W2212178620 cites W1963620791 @default.
• W2212178620 cites W1964003049 @default.
• W2212178620 cites W1966965406 @default.
• W2212178620 cites W1967369040 @default.
• W2212178620 cites W1969202007 @default.
• W2212178620 cites W1969723726 @default.
• W2212178620 cites W1973786421 @default.
• W2212178620 cites W1973873293 @default.
• W2212178620 cites W1978146026 @default.
• W2212178620 cites W1979455783 @default.
• W2212178620 cites W1985638466 @default.
• W2212178620 cites W1987977026 @default.
• W2212178620 cites W1994486988 @default.
• W2212178620 cites W1996701485 @default.
• W2212178620 cites W1996824979 @default.
• W2212178620 cites W2000834719 @default.
• W2212178620 cites W2000988653 @default.
• W2212178620 cites W2004219612 @default.
• W2212178620 cites W2005752004 @default.
• W2212178620 cites W2011213256 @default.
• W2212178620 cites W2014651657 @default.
• W2212178620 cites W2021261124 @default.
• W2212178620 cites W2023590131 @default.
• W2212178620 cites W2026369794 @default.
• W2212178620 cites W2027751877 @default.
• W2212178620 cites W2028422152 @default.
• W2212178620 cites W2029863584 @default.
• W2212178620 cites W2031551277 @default.
• W2212178620 cites W2034450973 @default.
• W2212178620 cites W2040559866 @default.
• W2212178620 cites W2044967254 @default.
• W2212178620 cites W2049352510 @default.
• W2212178620 cites W2059599491 @default.
• W2212178620 cites W2060190614 @default.
• W2212178620 cites W2067685745 @default.
• W2212178620 cites W2069029898 @default.
• W2212178620 cites W2072397017 @default.
• W2212178620 cites W2078421568 @default.
• W2212178620 cites W2078579292 @default.
• W2212178620 cites W2080834679 @default.
• W2212178620 cites W2085133707 @default.
• W2212178620 cites W2086657415 @default.
• W2212178620 cites W2088960215 @default.
• W2212178620 cites W2089631167 @default.
• W2212178620 cites W2091899875 @default.
• W2212178620 cites W2101037145 @default.
• W2212178620 cites W2102430660 @default.
• W2212178620 cites W2105716728 @default.
• W2212178620 cites W2112775060 @default.
• W2212178620 cites W2114329037 @default.
• W2212178620 cites W2116151124 @default.
• W2212178620 cites W2116698256 @default.
• W2212178620 cites W2116699880 @default.
• W2212178620 cites W2117691753 @default.
• W2212178620 cites W2119910918 @default.
• W2212178620 cites W2122101578 @default.
• W2212178620 cites W2122848220 @default.
• W2212178620 cites W2125411106 @default.
• W2212178620 cites W2129168171 @default.
• W2212178620 cites W2130458810 @default.
• W2212178620 cites W2130710544 @default.
• W2212178620 cites W2132936904 @default.
• W2212178620 cites W2134274937 @default.
• W2212178620 cites W2134636221 @default.
• W2212178620 cites W2135997854 @default.
• W2212178620 cites W2137016644 @default.
• W2212178620 cites W2140524267 @default.
• W2212178620 cites W2141157874 @default.
• W2212178620 cites W2142196041 @default.
• W2212178620 cites W2144805902 @default.
• W2212178620 cites W2145223987 @default.
• W2212178620 cites W2146397496 @default.
• W2212178620 cites W2146400232 @default.
• W2212178620 cites W2150037519 @default.
• W2212178620 cites W2152119362 @default.
• W2212178620 cites W2152207030 @default.
• W2212178620 cites W2154521171 @default.
• W2212178620 cites W2159319217 @default.
• W2212178620 cites W2160249463 @default.

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