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• W2212189098 abstract "This study was conducted to evaluate non-invasive predictive models of evaluating the presence of esophageal varices in patients diagnosed with liver cirrhosis. A retrospective cross sectional study on 101 patients diagnosed with liver cirrhosis was taken from January 1, 2012 to December 31, 2013. Diagnosis was based on clinical history, biochemical and ultrasonographic findings. Platelet count, ultrasonographic bipolar spleen diameter, platelet count/spleen diameter ratio, Child-Pugh and serum albumin levels were parameters tested to predict the presence of esophageal varices. All patients had esophagogastroduodenoscopy. Data were gathered from the hospital’s medical records. Exclusion criteria: active bleeding, previous endoscopic sclerosis or band ligation of esophageal varies, previous surgery for portal hypertension or transjugular intrahepatic portosystemic stent shunt placement, hepatocellular carcinoma, spontaneous bacterial peritonitis, or portal vein thrombosis, schistosomiasis and liver abscess. All data were tabulated and descriptive analysis were performed. P ≤ .05 was considered significant. Receiver Operating Characteristics Curve (ROC Curves), were applied to the variables. Statistical Package for Social Sciences (SSPS version 17) was used in computation. Patients were in their 6th decade of life (mean 64.8 versus 61.6, P = .41). 86 (85.1%) were diagnosed with esophageal varices. Male preponderance in patients with varices (64% versus 33.3%, P = .026) was noted. Alcohol was the most common etiology in those with varices (43% versus 13.3%, hepatitis B- 27.9% versus 20%), while non-alcoholic fatty liver disease was more noted in those without esophageal varices (66.7% versus 24.4%, P = .023). The platelet count/spleen diameter ratio showed a trend for association with esophageal varices but this did not reach statistical significance (OR 54.8, 95% CI 0.20-150, P = .16) The best predictive cut off of the platelet-spleen diameter ratio in this study was derived to be at ≤1.86. This had a positive predictive value of 89% (95% CI 80.4-94.9) and negative predictive value of 33% (13.3-59%). The sensitivity of this cut off was at 86% (95% CI 76.9-92.6%). The rest of the laboratory parameters were likewise not accurately predictive. Based on this study, platelet count/spleen diameter ratio only showed a trend for association with esophageal varices but this did not reach statistical significance. Other parameters were not able to predict esophageal varices, though several cut off values were determined which may assist clinicians in stratifying patient who would benefit from esophagogastroduodenoscopy. These parameters could later be validated with a greater sample size." @default.
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• W2212189098 date "2015-07-01" @default.
• W2212189098 modified "2023-09-27" @default.
• W2212189098 title "A Retrospective Study on Noninvasive Predictors of Esophageal Varices in Patients With Liver Cirrhosis: A Makati Medical Center Experience" @default.
• W2212189098 doi "https://doi.org/10.1016/j.cgh.2015.04.061" @default.
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