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- W221224410 endingPage "11" @default.
- W221224410 startingPage "11" @default.
- W221224410 abstract "After the first observation of the immunosuppressive effects of ultraviolet (UV) irradiation was reported in 1974, therapeutic modification of immune responses by UV irradiation began to be investigated in the context immunization. UV-induced immunosuppression is via the action of regulatory T cells (Tregs). Antigen-specific Tregs were induced by high-dose UV-B irradiation before antigen immunization in many studies, as it was considered that functional alteration and/or modulation of antigen-presenting cells by UV irradiation was required for the induction of antigen-specific immunosuppression. However, it is also reported that UV irradiation after immunization induces antigen-specific Tregs. UV-induced Tregs are also dominantly transferable, with interleukin-10 being important for UV-induced immunosuppression. Currently, various possible mechanisms involving Treg phenotype and cytokine profile have been suggested. UV irradiation accompanied by alloantigen immunization induces alloantigen-specific transferable Tregs, which have potential therapeutic applications in the transplantation field. Here we review the current status of UV-induced antigen-specific immunosuppression on the 40(th) anniversary of its discovery." @default.
- W221224410 created "2016-06-24" @default.
- W221224410 creator A5005828577 @default.
- W221224410 creator A5023921886 @default.
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- W221224410 creator A5072168969 @default.
- W221224410 creator A5082728441 @default.
- W221224410 date "2015-01-01" @default.
- W221224410 modified "2023-10-16" @default.
- W221224410 title "Ultraviolet-induced alloantigen-specific immunosuppression in transplant immunity" @default.
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