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• W2212308839 endingPage "1013" @default.
• W2212308839 startingPage "1005" @default.
• W2212308839 abstract "Titanium dioxide nanoparticles (n-TiO2) and bisphenol A (BPA) are widespread environmental contaminants in the aquatic environment. We hypothesized that n-TiO2 may adsorb BPA, and thus modify its bioavailability and toxicity to aquatic organisms. In this study, the bioavailability and toxicity of BPA (0, 2, 20, 200 μg/L) was investigated in the presence of n-TiO2 (100 μg/L). The n-TiO2 sorbed BPA and the resulting nanoparticles were taken up by zebrafish, where they translocated to the liver, brain, and gonad tissues. Increased tissue burdens of both BPA and n-TiO2 were observed following coexposure, and they also caused a reduction in plasma concentrations of estradiol (E2), testosterone (T), follicle-stimulating hormone (FSH), and luteinizing hormone (LH). Plasma vitellogenin (VTG) concentrations were significantly increased in males and females upon exposure to BPA. Histological examination of the ovary and testes did not show obvious morphological alterations; however, inhibition of egg production was noted in the presence of n-TiO2. The results indicated that n-TiO2 acts as a carrier of BPA and enhances its bioconcentration in zebrafish, leading to endocrine disruption and impairment of reproduction." @default.
• W2212308839 created "2016-06-24" @default.
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• W2212308839 date "2016-01-04" @default.
• W2212308839 modified "2023-10-12" @default.
• W2212308839 title "Enhanced Bioconcentration of Bisphenol A in the Presence of Nano-TiO₂ Can Lead to Adverse Reproductive Outcomes in Zebrafish" @default.
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• W2212308839 doi "https://doi.org/10.1021/acs.est.5b05024" @default.
• W2212308839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26694738" @default.
• W2212308839 hasPublicationYear "2016" @default.
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