FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2212496351> ?p ?o ?g. }

• W2212496351 endingPage "78" @default.
• W2212496351 startingPage "267" @default.
• W2212496351 abstract "The purpose of this study was to examine the effect of gemcitabine (GEM) on microRNA-218 (miR-218) expression in human pancreatic cancer cells.Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was performed to examine the differences in miR-218 expression between the GEM-sensitive BxPC-3 pancreatic cancer cells and GEM-resistant PANC-1 cells. The effect of GEM on the expression of miR-218 in PANC-1 cells was also investigated. PANC-1 cells were transfected either with HMGB1 siRNA to knock down the expression of HMGB1 or with the recombinant HMGB1 expression vector (pcDNA3.1-HMGB1) to overexpress HMGB1. The effect of ectopic expression of HMGB1 on the apoptosis of miR-218-transfected and GEM-treated PANC-1 cells was examined by flow cytometric analysis.The miR-218 expression level was lower in GEM-resistant PANC-1 cells compared to GEM-sensitive BxPC-3 cells (P<0.05). The percentage of apoptotic PANC-1 cells was significantly increased in the miR-218 mimic + GEM group compared to the mimic ctrl + GEM group and the normal control group (P<0.01). The HMGB1 expression level was markedly decreased in PANC-1 cells transfected with HMGB1 siRNA but was significantly increased in PANC-1 cells transfected with the recombinant HMGB1 expression vector, pcDNA3.1-HMGB1 (P<0.01). The proportion of apoptotic PANC-1 cells was significantly lower in the miR-218 mimic + GEM + pcDNA3.1-HMGB1 group compared to the miR-218 mimic + GEM + HMGB1 siRNA group (P<0.01).The expression level of miR-218 was downregulated in the GEM-resistant cell line. miR-218 promoted the sensitivity of PANC-1 cells to GEM, which was achieved mainly through regulating the expression of HMGB1 in PANC-1 cells." @default.
• W2212496351 created "2016-06-24" @default.
• W2212496351 creator A5015124133 @default.
• W2212496351 creator A5037586182 @default.
• W2212496351 creator A5043644940 @default.
• W2212496351 creator A5054859641 @default.
• W2212496351 creator A5061196306 @default.
• W2212496351 creator A5067283047 @default.
• W2212496351 creator A5091161457 @default.
• W2212496351 date "2015-06-01" @default.
• W2212496351 modified "2023-09-25" @default.
• W2212496351 title "microRNA-218 promotes gemcitabine sensitivity in human pancreatic cancer cells by regulating HMGB1 expression." @default.
• W2212496351 cites W1480172283 @default.
• W2212496351 cites W1500693877 @default.
• W2212496351 cites W1505228537 @default.
• W2212496351 cites W153237623 @default.
• W2212496351 cites W1556401947 @default.
• W2212496351 cites W1870407395 @default.
• W2212496351 cites W1873821844 @default.
• W2212496351 cites W1909768921 @default.
• W2212496351 cites W1943064845 @default.
• W2212496351 cites W1966226573 @default.
• W2212496351 cites W1967000460 @default.
• W2212496351 cites W1980320445 @default.
• W2212496351 cites W1990505414 @default.
• W2212496351 cites W1990909403 @default.
• W2212496351 cites W1997622446 @default.
• W2212496351 cites W2005714581 @default.
• W2212496351 cites W2008801574 @default.
• W2212496351 cites W2009628911 @default.
• W2212496351 cites W2020259214 @default.
• W2212496351 cites W2027158730 @default.
• W2212496351 cites W2028640470 @default.
• W2212496351 cites W2035762739 @default.
• W2212496351 cites W2036756052 @default.
• W2212496351 cites W2048813922 @default.
• W2212496351 cites W2052092440 @default.
• W2212496351 cites W2057680622 @default.
• W2212496351 cites W2059646167 @default.
• W2212496351 cites W2066907818 @default.
• W2212496351 cites W2074182195 @default.
• W2212496351 cites W2083085197 @default.
• W2212496351 cites W2085633479 @default.
• W2212496351 cites W2085698158 @default.
• W2212496351 cites W2101268389 @default.
• W2212496351 cites W2107033660 @default.
• W2212496351 cites W2112197865 @default.
• W2212496351 cites W2115047843 @default.
• W2212496351 cites W2117549505 @default.
• W2212496351 cites W2121059143 @default.
• W2212496351 cites W2121929971 @default.
• W2212496351 cites W2143866789 @default.
• W2212496351 cites W2159104053 @default.
• W2212496351 cites W2162182198 @default.
• W2212496351 cites W2165480504 @default.
• W2212496351 cites W2168709731 @default.
• W2212496351 cites W2171738609 @default.
• W2212496351 cites W2176103098 @default.
• W2212496351 cites W2283770838 @default.
• W2212496351 cites W2855694 @default.
• W2212496351 cites W4252044669 @default.
• W2212496351 doi "https://doi.org/10.3978/j.issn.1000-9604.2015.04.06" @default.
• W2212496351 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4490198" @default.
• W2212496351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26157323" @default.
• W2212496351 hasPublicationYear "2015" @default.
• W2212496351 type Work @default.
• W2212496351 sameAs 2212496351 @default.
• W2212496351 citedByCount "11" @default.
• W2212496351 countsByYear W22124963512016 @default.
• W2212496351 countsByYear W22124963512017 @default.
• W2212496351 countsByYear W22124963512018 @default.
• W2212496351 countsByYear W22124963512019 @default.
• W2212496351 countsByYear W22124963512020 @default.
• W2212496351 crossrefType "journal-article" @default.
• W2212496351 hasAuthorship W2212496351A5015124133 @default.
• W2212496351 hasAuthorship W2212496351A5037586182 @default.
• W2212496351 hasAuthorship W2212496351A5043644940 @default.
• W2212496351 hasAuthorship W2212496351A5054859641 @default.
• W2212496351 hasAuthorship W2212496351A5061196306 @default.
• W2212496351 hasAuthorship W2212496351A5067283047 @default.
• W2212496351 hasAuthorship W2212496351A5091161457 @default.
• W2212496351 hasConcept C104317684 @default.
• W2212496351 hasConcept C121608353 @default.
• W2212496351 hasConcept C126322002 @default.
• W2212496351 hasConcept C145059251 @default.
• W2212496351 hasConcept C153911025 @default.
• W2212496351 hasConcept C185592680 @default.
• W2212496351 hasConcept C190283241 @default.
• W2212496351 hasConcept C203014093 @default.
• W2212496351 hasConcept C2776914184 @default.
• W2212496351 hasConcept C2780210213 @default.
• W2212496351 hasConcept C2780258809 @default.
• W2212496351 hasConcept C2780545709 @default.
• W2212496351 hasConcept C33161422 @default.
• W2212496351 hasConcept C40767141 @default.
• W2212496351 hasConcept C502942594 @default.
• W2212496351 hasConcept C54009773 @default.
• W2212496351 hasConcept C54355233 @default.

• next