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- W2212792660 endingPage "141" @default.
- W2212792660 startingPage "76" @default.
- W2212792660 abstract "Heparin has been recognized as a valuable anticoagulant and antithrombotic for several decades and is still widely used in clinical practice for a variety of indications. The anticoagulant activity of heparin is mainly attributable to the action of a specific pentasaccharide sequence that acts in concert with antithrombin, a plasma coagulation factor inhibitor. This observation has led to the development of synthetic heparin mimetics for clinical use. However, it is increasingly recognized that heparin has many other pharmacological properties, including but not limited to antiviral, anti-inflammatory, and antimetastatic actions. Many of these activities are independent of its anticoagulant activity, although the mechanisms of these other activities are currently less well defined. Nonetheless, heparin is being exploited for clinical uses beyond anticoagulation and developed for a wide range of clinical disorders. This article provides a state of the art review of our current understanding of the pharmacology of heparin and related drugs and an overview of the status of development of such drugs." @default.
- W2212792660 created "2016-06-24" @default.
- W2212792660 creator A5002580754 @default.
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- W2212792660 creator A5036493196 @default.
- W2212792660 creator A5054982987 @default.
- W2212792660 creator A5066607321 @default.
- W2212792660 date "2015-12-15" @default.
- W2212792660 modified "2023-10-12" @default.
- W2212792660 title "Pharmacology of Heparin and Related Drugs" @default.
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