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- W2212795645 abstract "Hepatocytes are targeted for infection by a number of major human pathogens, including hepatitis B virus, hepatitis C virus, and malaria. However, hepatocytes are also immunological agents in their own right. In systemic immunity, they are central in the acute-phase response, which floods the circulation with defensive proteins during diverse stresses, including ischemia, physical trauma, and sepsis. Hepatocytes express a variety of innate immune receptors and, when challenged with pathogen- or damage-associated molecular patterns, can deliver cell-autonomous innate immune responses that may result in host defense or in immunopathology. Important human pathogens have evolved mechanisms to subvert these responses. Finally, hepatocytes talk directly to T cells, resulting in a bias toward immune tolerance." @default.
- W2212795645 created "2016-06-24" @default.
- W2212795645 creator A5018427690 @default.
- W2212795645 date "2015-12-18" @default.
- W2212795645 modified "2023-10-15" @default.
- W2212795645 title "Hepatocytes as Immunological Agents" @default.
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- W2212795645 doi "https://doi.org/10.4049/jimmunol.1501668" @default.
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