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- W2212896768 abstract "The myosin heavy chain (MHC) exists as multiple isoforms that are encoded for by a family of genes. The respiratory musculature demonstrates muscle-specific and temporally-dependent changes in MHC isoform expression during maturation. Developmental expression of MHC isoforms correlate well with postnatal changes in actomyosin ATPase activity, specific force generation (P0/CSA), maximum unloaded velocity of shortening (V0) and and fatigue resistance. More specifically, as the expression of MHCneonatal declines and MHC2A, MHC2X, and MHC2B increase, actomyosin ATPase activity, P0/CSA, V0, and muscle fatigability increase. The increase in actomyosin ATPase activity with maturation is partially offset by a postnatal increase in oxidative capacity; however, as fatigue resistance declines with development it is apparent that the energy costs of contraction are not fully matched by an increase in energy production. Developmental transitions in smooth muscle MHC phenotype also occur although their functional importance remains unclear." @default.
- W2212896768 created "2016-06-24" @default.
- W2212896768 creator A5002905299 @default.
- W2212896768 creator A5029730467 @default.
- W2212896768 creator A5056573681 @default.
- W2212896768 date "1998-03-01" @default.
- W2212896768 modified "2023-10-15" @default.
- W2212896768 title "Myosin heavy chain transitions during development" @default.
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- W2212896768 doi "https://doi.org/10.1016/s0305-0491(98)00006-6" @default.
- W2212896768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9734330" @default.
- W2212896768 hasPublicationYear "1998" @default.
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