FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2212897984> ?p ?o ?g. }

• W2212897984 endingPage "2358" @default.
• W2212897984 startingPage "2351" @default.
• W2212897984 abstract "Abstract Purpose: Rearranged ROS1 is a crizotinib-sensitive oncogenic driver in lung cancer. The development of acquired resistance, however, poses a serious clinical challenge. Consequently, experimental and clinical validation of resistance mechanisms and potential second-line therapies is essential. Experimental Design: We report the discovery of a novel, solvent-front ROS1D2033N mutation in a patient with CD74-ROS1–rearranged lung adenocarcinoma and acquired resistance to crizotinib. Crizotinib resistance of CD74-ROS1D2033N was functionally evaluated using cell-based assays and structural modeling. Results: In biochemical and cell-based assays, the CD74-ROS1D2033N mutant demonstrated significantly decreased sensitivity to crizotinib. Molecular dynamics simulation revealed compromised crizotinib binding due to drastic changes in the electrostatic interaction between the D2033 residue and crizotinib and reorientation of neighboring residues. In contrast, cabozantinib binding was unaffected by the D2033N substitution, and inhibitory potency against the mutant was retained. Notably, cabozantinib treatment resulted in a rapid clinical and near-complete radiographic response in this patient. Conclusions: These results provide the first example of successful therapeutic intervention with targeted therapy to overcome crizotinib resistance in a ROS1-rearranged cancer. Clin Cancer Res; 22(10); 2351–8. ©2015 AACR." @default.
• W2212897984 created "2016-06-24" @default.
• W2212897984 creator A5029484872 @default.
• W2212897984 creator A5029672494 @default.
• W2212897984 creator A5030479930 @default.
• W2212897984 creator A5030828526 @default.
• W2212897984 creator A5031045426 @default.
• W2212897984 creator A5034017276 @default.
• W2212897984 creator A5039382617 @default.
• W2212897984 creator A5039791495 @default.
• W2212897984 creator A5045185741 @default.
• W2212897984 creator A5045437866 @default.
• W2212897984 creator A5046345178 @default.
• W2212897984 creator A5046460245 @default.
• W2212897984 creator A5050638774 @default.
• W2212897984 creator A5053263729 @default.
• W2212897984 creator A5060033755 @default.
• W2212897984 creator A5063199354 @default.
• W2212897984 date "2016-05-12" @default.
• W2212897984 modified "2023-10-14" @default.
• W2212897984 title "A Novel Crizotinib-Resistant Solvent-Front Mutation Responsive to Cabozantinib Therapy in a Patient with <i>ROS1</i>-Rearranged Lung Cancer" @default.
• W2212897984 cites W1972758026 @default.
• W2212897984 cites W1976499671 @default.
• W2212897984 cites W1981225934 @default.
• W2212897984 cites W1990626198 @default.
• W2212897984 cites W1996804310 @default.
• W2212897984 cites W1997505729 @default.
• W2212897984 cites W2008167816 @default.
• W2212897984 cites W2019607817 @default.
• W2212897984 cites W2022948223 @default.
• W2212897984 cites W2029582401 @default.
• W2212897984 cites W2030702185 @default.
• W2212897984 cites W2052546787 @default.
• W2212897984 cites W2065799563 @default.
• W2212897984 cites W2067174909 @default.
• W2212897984 cites W2081801534 @default.
• W2212897984 cites W2083164919 @default.
• W2212897984 cites W2088757697 @default.
• W2212897984 cites W2102377211 @default.
• W2212897984 cites W2103110584 @default.
• W2212897984 cites W2103945336 @default.
• W2212897984 cites W2111254482 @default.
• W2212897984 cites W2116999806 @default.
• W2212897984 cites W2119317963 @default.
• W2212897984 cites W2127129900 @default.
• W2212897984 cites W2130488043 @default.
• W2212897984 cites W2137460778 @default.
• W2212897984 cites W2150981663 @default.
• W2212897984 cites W2157687487 @default.
• W2212897984 cites W223909586 @default.
• W2212897984 cites W2332712348 @default.
• W2212897984 doi "https://doi.org/10.1158/1078-0432.ccr-15-2013" @default.
• W2212897984 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4867287" @default.
• W2212897984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26673800" @default.
• W2212897984 hasPublicationYear "2016" @default.
• W2212897984 type Work @default.
• W2212897984 sameAs 2212897984 @default.
• W2212897984 citedByCount "128" @default.
• W2212897984 countsByYear W22128979842016 @default.
• W2212897984 countsByYear W22128979842017 @default.
• W2212897984 countsByYear W22128979842018 @default.
• W2212897984 countsByYear W22128979842019 @default.
• W2212897984 countsByYear W22128979842020 @default.
• W2212897984 countsByYear W22128979842021 @default.
• W2212897984 countsByYear W22128979842022 @default.
• W2212897984 countsByYear W22128979842023 @default.
• W2212897984 crossrefType "journal-article" @default.
• W2212897984 hasAuthorship W2212897984A5029484872 @default.
• W2212897984 hasAuthorship W2212897984A5029672494 @default.
• W2212897984 hasAuthorship W2212897984A5030479930 @default.
• W2212897984 hasAuthorship W2212897984A5030828526 @default.
• W2212897984 hasAuthorship W2212897984A5031045426 @default.
• W2212897984 hasAuthorship W2212897984A5034017276 @default.
• W2212897984 hasAuthorship W2212897984A5039382617 @default.
• W2212897984 hasAuthorship W2212897984A5039791495 @default.
• W2212897984 hasAuthorship W2212897984A5045185741 @default.
• W2212897984 hasAuthorship W2212897984A5045437866 @default.
• W2212897984 hasAuthorship W2212897984A5046345178 @default.
• W2212897984 hasAuthorship W2212897984A5046460245 @default.
• W2212897984 hasAuthorship W2212897984A5050638774 @default.
• W2212897984 hasAuthorship W2212897984A5053263729 @default.
• W2212897984 hasAuthorship W2212897984A5060033755 @default.
• W2212897984 hasAuthorship W2212897984A5063199354 @default.
• W2212897984 hasBestOaLocation W22128979841 @default.
• W2212897984 hasConcept C121608353 @default.
• W2212897984 hasConcept C126322002 @default.
• W2212897984 hasConcept C143998085 @default.
• W2212897984 hasConcept C2775999482 @default.
• W2212897984 hasConcept C2776232967 @default.
• W2212897984 hasConcept C2776256026 @default.
• W2212897984 hasConcept C2779422266 @default.
• W2212897984 hasConcept C2781064419 @default.
• W2212897984 hasConcept C2781182431 @default.
• W2212897984 hasConcept C502942594 @default.
• W2212897984 hasConcept C71924100 @default.
• W2212897984 hasConceptScore W2212897984C121608353 @default.
• W2212897984 hasConceptScore W2212897984C126322002 @default.
• W2212897984 hasConceptScore W2212897984C143998085 @default.

• next