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• W2212918063 endingPage "126" @default.
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• W2212918063 abstract "The aim of this systematic review and meta-analysis was to evaluate the effect of exercise training on parameters of the renin–angiotensin–aldosterone system (RAAS) in healthy adults, and to investigate the relation with training induced changes in blood pressure. A systematic search was conducted and we included randomized controlled trials lasting ⩾4 weeks investigating the effects of exercise on parameters of the RAAS in healthy adults (age ⩾18 years) and published in a peer-reviewed journal up to December 2013. Fixed effects models were used and data are reported as weighted means and 95% confidence limits (CL). Eleven randomized controlled trials with a total of 375 individuals were included. Plasma renin activity was reduced after exercise training (n= 7 trials, standardized mean difference −0.25 (95% CL −0.5 to −0.001), P=0.049), whereas no effect was observed on serum aldosterone ((n= 3 trials; standardized mean difference −0.79 (−1.97 to +0.39)) or angiotensin II (n=3 trials; standardized mean difference −0.16 (−0.61 to +0.30). Significant reductions in systolic blood pressure −5.65 mm Hg (−8.12 to −3.17) and diastolic blood pressure −3.64 mm Hg (−5.4 to −1.91) following exercise training were observed. No relation was found between net changes in plasma renin activity and net changes in blood pressure (P>0.05). To conclude, although we observed a significant reduction in plasma renin activity following exercise training this was not related to the observed blood pressure reduction. Given the small number of studies and small sample sizes, larger well-controlled randomized studies are required to confirm our results and to investigate the potential role of the RAAS in the observed improvements in blood pressure following exercise training." @default.
• W2212918063 created "2016-06-24" @default.
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• W2212918063 creator A5024059093 @default.
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• W2212918063 date "2015-09-24" @default.
• W2212918063 modified "2023-10-10" @default.
• W2212918063 title "Effect of exercise training on the renin–angiotensin–aldosterone system in healthy individuals: a systematic review and meta-analysis" @default.
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• W2212918063 doi "https://doi.org/10.1038/hr.2015.100" @default.
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