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• W2213076469 abstract "BACKGROUND Various transmission routes contribute to spread of carbapenem-resistant Klebsiella pneumoniae (CRKP) in hospitalized patients. Patients with readmissions during which CRKP is again isolated (“CRKP readmission”) potentially contribute to transmission of CRKP. OBJECTIVE To evaluate CRKP readmissions in the Consortium on Resistance against Carbapenems in K. pneumoniae (CRaCKLe). DESIGN Cohort study from December 24, 2011, through July 1, 2013. SETTING Multicenter consortium of acute care hospitals in the Great Lakes region. PATIENTS All patients who were discharged alive during the study period were included. Each patient was included only once at the time of the first CRKP-positive culture. METHODS All readmissions within 90 days of discharge from the index hospitalization during which CRKP was again found were analyzed. Risk factors for CRKP readmission were evaluated in multivariable models. RESULTS Fifty-six (20%) of 287 patients who were discharged alive had a CRKP readmission. History of malignancy was associated with CRKP readmission (adjusted odds ratio [adjusted OR], 3.00 [95% CI, 1.32–6.65], P <.01). During the index hospitalization, 160 patients (56%) received antibiotic treatment against CRKP; the choice of regimen was associated with CRKP readmission ( P=. 02). Receipt of tigecycline-based therapy (adjusted OR, 5.13 [95% CI, 1.72–17.44], using aminoglycoside-based therapy as a reference in those treated with anti-CRKP antibiotics) was associated with CRKP readmission. CONCLUSION Hospitalized patients with CRKP—specifically those with a history of malignancy—are at high risk of readmission with recurrent CRKP infection or colonization. Treatment during the index hospitalization with a tigecycline-based regimen increases this risk. Infect. Control Hosp. Epidemiol. 2016;37(3):281–288" @default.
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• W2213076469 date "2015-12-21" @default.
• W2213076469 modified "2023-10-11" @default.
• W2213076469 title "Hospital Readmissions in Patients With Carbapenem-Resistant Klebsiella pneumoniae" @default.
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• W2213076469 doi "https://doi.org/10.1017/ice.2015.298" @default.
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