FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2213144761> ?p ?o ?g. }

• W2213144761 endingPage "71" @default.
• W2213144761 startingPage "63" @default.
• W2213144761 abstract "Chronic inflammatory diseases, such as rheumatoid arthritis and periodontitis-caused bone destruction, results from an increase of bone-resorbing osteoclasts (OCs) induced by inflammation. However, the detailed mechanisms underlying this disorder remain unclear. We herein investigated that the effect of urokinase-type plasminogen activator (uPA) on inflammatory osteoclastogenesis induced by lipopolysaccharide (LPS), which is a potent stimulator of bone resorption in inflammatory diseases. We found that the uPA deficiency promoted inflammatory osteoclastogenesis and bone loss induced by LPS. We also showed that LPS induced the expression of uPA, and the uPA treatment attenuated the LPS-induced inflammatory osteoclastogenesis of RAW264.7 mouse monocyte/macrophage lineage cells. Additionally, we showed that the uPA-attenuated inflammatory osteoclastgenesis is associated with the activation of plasmin/protease-activated receptor (PAR)-1 axis by uPA. Moreover, we examined the mechanism underlying the effect of uPA on inflammatory osteoclastogenesis, and found that uPA/plasmin/PAR-1 activated the adenosine monophosphate-activated protein kinase (AMPK) pathway through Ca2+/calmodulin dependent protein kinase kinase (CaMKK) activation, and attenuated inflammatory osteoclastogenesis by inactivation of NF-κB in RAW264.7 cells. These data suggest that uPA attenuated inflammatory osteoclastogenesis through the plasmin/PAR-1/Ca2+/CaMKK/AMPK axis. Our findings may provide a novel therapeutic approach to bone loss caused by inflammatory diseases." @default.
• W2213144761 created "2016-06-24" @default.
• W2213144761 creator A5009408667 @default.
• W2213144761 creator A5027765839 @default.
• W2213144761 creator A5040680020 @default.
• W2213144761 creator A5044523034 @default.
• W2213144761 creator A5061328417 @default.
• W2213144761 creator A5071323004 @default.
• W2213144761 date "2016-01-01" @default.
• W2213144761 modified "2023-10-05" @default.
• W2213144761 title "uPA Attenuated LPS-induced Inflammatory Osteoclastogenesis through the Plasmin/PAR-1/Ca²⁺/CaMKK/AMPK Axis" @default.
• W2213144761 cites W1567817045 @default.
• W2213144761 cites W1774668126 @default.
• W2213144761 cites W1851359827 @default.
• W2213144761 cites W1964066819 @default.
• W2213144761 cites W1973104883 @default.
• W2213144761 cites W1974471520 @default.
• W2213144761 cites W1987705105 @default.
• W2213144761 cites W1992644897 @default.
• W2213144761 cites W2000989835 @default.
• W2213144761 cites W2001158499 @default.
• W2213144761 cites W2004316687 @default.
• W2213144761 cites W2012546262 @default.
• W2213144761 cites W2014001027 @default.
• W2213144761 cites W2014225480 @default.
• W2213144761 cites W2014770452 @default.
• W2213144761 cites W2015267043 @default.
• W2213144761 cites W2022351216 @default.
• W2213144761 cites W2022359531 @default.
• W2213144761 cites W2024038461 @default.
• W2213144761 cites W2029884260 @default.
• W2213144761 cites W2031202094 @default.
• W2213144761 cites W2038227076 @default.
• W2213144761 cites W2052133198 @default.
• W2213144761 cites W2072335952 @default.
• W2213144761 cites W2072878985 @default.
• W2213144761 cites W2073270002 @default.
• W2213144761 cites W2075176477 @default.
• W2213144761 cites W2081323226 @default.
• W2213144761 cites W2083874421 @default.
• W2213144761 cites W2090145292 @default.
• W2213144761 cites W2093252878 @default.
• W2213144761 cites W2115957809 @default.
• W2213144761 cites W2118417281 @default.
• W2213144761 cites W2126027415 @default.
• W2213144761 cites W2132623788 @default.
• W2213144761 cites W2138226825 @default.
• W2213144761 cites W2142072453 @default.
• W2213144761 cites W2142547084 @default.
• W2213144761 cites W2157744153 @default.
• W2213144761 cites W2162485603 @default.
• W2213144761 cites W2162562820 @default.
• W2213144761 cites W2165511735 @default.
• W2213144761 cites W2167246791 @default.
• W2213144761 cites W2169417490 @default.
• W2213144761 cites W2407533327 @default.
• W2213144761 cites W2425168405 @default.
• W2213144761 cites W287939238 @default.
• W2213144761 doi "https://doi.org/10.7150/ijbs.12690" @default.
• W2213144761 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4679399" @default.
• W2213144761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26722218" @default.
• W2213144761 hasPublicationYear "2016" @default.
• W2213144761 type Work @default.
• W2213144761 sameAs 2213144761 @default.
• W2213144761 citedByCount "38" @default.
• W2213144761 countsByYear W22131447612016 @default.
• W2213144761 countsByYear W22131447612017 @default.
• W2213144761 countsByYear W22131447612018 @default.
• W2213144761 countsByYear W22131447612019 @default.
• W2213144761 countsByYear W22131447612020 @default.
• W2213144761 countsByYear W22131447612021 @default.
• W2213144761 countsByYear W22131447612022 @default.
• W2213144761 countsByYear W22131447612023 @default.
• W2213144761 crossrefType "journal-article" @default.
• W2213144761 hasAuthorship W2213144761A5009408667 @default.
• W2213144761 hasAuthorship W2213144761A5027765839 @default.
• W2213144761 hasAuthorship W2213144761A5040680020 @default.
• W2213144761 hasAuthorship W2213144761A5044523034 @default.
• W2213144761 hasAuthorship W2213144761A5061328417 @default.
• W2213144761 hasAuthorship W2213144761A5071323004 @default.
• W2213144761 hasBestOaLocation W22131447611 @default.
• W2213144761 hasConcept C126322002 @default.
• W2213144761 hasConcept C134018914 @default.
• W2213144761 hasConcept C181199279 @default.
• W2213144761 hasConcept C184235292 @default.
• W2213144761 hasConcept C185592680 @default.
• W2213144761 hasConcept C2776914184 @default.
• W2213144761 hasConcept C2778754761 @default.
• W2213144761 hasConcept C2780124434 @default.
• W2213144761 hasConcept C2781071845 @default.
• W2213144761 hasConcept C2781184567 @default.
• W2213144761 hasConcept C502942594 @default.
• W2213144761 hasConcept C55493867 @default.
• W2213144761 hasConcept C673006 @default.
• W2213144761 hasConcept C71924100 @default.
• W2213144761 hasConcept C97029542 @default.
• W2213144761 hasConceptScore W2213144761C126322002 @default.
• W2213144761 hasConceptScore W2213144761C134018914 @default.

• next