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- W2213156766 abstract "The processes underlying the etiology of cancer have been the fodder for several theories for a century (for a discussion of the earliest theories, see the subsequent discussion and previous studies). Central to all these theories is the cell of origin for the transformation from a normal to a cancerous cell. The prevailing hypothesis, until recent years, was that any cell that had acquired multiple genetic hits could give rise to a tumor. The cancer stem cell hypothesis posits that only a small subset of cells, termed tumor-initiating cells or cancer stem cells (CSCs), is capable of giving rise to and maintaining tumors. Therefore all CSCs must display several characteristics: they must be the only cells that are capable of giving rise to a tumor (tumorigenic), they must be able to maintain the population of tumorigenic cells (self-renewal), and they must be able to give rise to the heterogeneous cells composing the entire tumor (pluripotency). When a CSC is transplanted into an immunocompromised mouse, self-renewal and pluripotency are vital for the formation of a tumor that recapitulates the original (reviewed by Wang and Dick)." @default.
- W2213156766 created "2016-06-24" @default.
- W2213156766 creator A5012494061 @default.
- W2213156766 creator A5031063483 @default.
- W2213156766 date "2009-08-24" @default.
- W2213156766 modified "2023-09-27" @default.
- W2213156766 title "Purification and characterization of cancer stem cells" @default.
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- W2213156766 doi "https://doi.org/10.1017/cbo9780511605536.002" @default.
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