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- W2213232708 abstract "6004 Background: Failure to publish clinical research carries important scientific and ethical consequences. Scientifically, publication of only positive results leads to an overestimation of the true efficacy of a new therapy. Ethically, failure to publish constitutes a breach of contract with the public, patients and sponsors who expect dissemination of the results. Previous studies have estimated that 7–51% of completed studies in medicine are not published (AIDS Edu Prev 1997;9:15–21). The publication rate of the NCI COGs is, however, not known. Methods: Eight COGs sponsored by the NCI have conducted and completed more than 30 RCTs each. We obtained a list of all completed phase III RCTs with details of their publication status from the main protocol office of the NCI, principal investigators and statistical offices from 4 of the COGs (table 1). We used the NCI definition of completed studies in the determination of the publication rate: studies that met their primary objectives, were closed to accrual and in which all patients have completed therapy. Studies that were initiated but were closed early due to poor accrual were excluded. Results: The number of trials included in this analysis range from 30 to 81 RCTs per COG. The publication rate ranged from 95 to 100% (table 1). Of 240 published studies, 98% were published as manuscripts while 2% were published as an abstract only. Conclusions: The publication rate of the NCI sponsored trials is high. The Cooperative Oncology Groups, which are sponsored by the NCI and publicly funded, have an outstanding publication record for their trials. This record minimizes publication bias, and ensures dissemination of the knowledge gained through the performance of clinical trials. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration US NIH (grant# R01 NS044417–01)" @default.
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- W2213232708 date "2004-07-15" @default.
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- W2213232708 title "Lack of publication bias in randomized clinical trials (RCTs) sponsored by the National Cancer Institute (NCI) and performed by Cooperative Oncology Groups (COGs)" @default.
- W2213232708 doi "https://doi.org/10.1200/jco.2004.22.90140.6004" @default.
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