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• W2213285461 abstract "Palbociclib, an oral small-molecule inhibitor of cyclin-dependent kinases 4 and 6, was recently approved by the U.S. Food and Drug Administration in combination with letrozole for postmenopausal women with advanced hormone receptor–positive, her2-negative breast cancer. Patients with loss of CDKN2A (p16), an inherent negative regulator of cyclin-dependent kinases 4 and 6, were not separately studied because of the significant response of the patients selected based only on receptor status. Here, we report a patient with metastatic estrogen receptor–positive, her2-negative breast cancer with CDKN2A loss who experienced a clinical response to palbociclib." @default.
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• W2213285461 date "2015-12-01" @default.
• W2213285461 modified "2023-09-26" @default.
• W2213285461 title "Does CDKN2A Loss Predict Palbociclib Benefit?" @default.
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• W2213285461 doi "https://doi.org/10.3747/co.22.2700" @default.
• W2213285461 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4687677" @default.
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