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- W2213441047 abstract "Individuals with mild cognitive impairment (MCI) have a high risk to develop dementia. A large number of variables appeared to be predictors of dementia in subjects with MCI. Subcortical vascular changes are frequently associated with cognitive impairment, however prognostic significance of presence white matter changes and/or lacunes on brain computed tomography (CT) in MCI patients remains unclear. To test the hypothesis that white matter changes and/or lacunes are overpresented in MCI patients with progressive course of the disease, when compared with stable MCI. The subjects of this study were 109 patients with MCI diagnosed according to the criteria proposed by Petersen et al. (1997). Four patients with history of stroke or transient ischemic attack were excluded. All subjects were given brain CT scan. The mean follow up period for the cohort was 2.2 years. At follow up, all patients were divided into 2 groups: I – 77 subjects with stable MCI course, II – 28 subjects with progressive symptoms of cognitive impairment or who converted to dementia. Frequency of presence of white matter changes and/or lacunes at the initial visit was compared between these two groups. Subcortical vascular changes were present significantly more frequently in group II (67.8%) than in group I (20.7%). Chi2 = 20.4, p< 0.001. Presence of subcortical vascular changes on brain CT is associated with increased risk of progressing course of cognitive impairment and dementia in our group of MCI patients." @default.
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- W2213441047 date "2006-07-01" @default.
- W2213441047 modified "2023-09-27" @default.
- W2213441047 title "P2-340: Prognostic significance of subcortical vascular changes in patients with MCI" @default.
- W2213441047 doi "https://doi.org/10.1016/j.jalz.2006.05.1180" @default.
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