Matches in SemOpenAlex for { <https://semopenalex.org/work/W2213462949> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2213462949 endingPage "10" @default.
- W2213462949 startingPage "203" @default.
- W2213462949 abstract "Matrix Metalloproteinases (MMPs) play an important role in gastric cancer (GC). Accumulated evidence suggests that functional MMP-1 and MMP-7 gene polymorphisms are associated with several tumors. The aim of this study was to investigate two single nucleotide polymorphisms, MMP-1 -1607 1G/2G and MMP-7 -181 A/G, and their potential relationship with GC. We examined 246 GC patients and 252 age-and sex-matched controls from Sichuan province in China. Genotypes were determined using a polymerase chain reaction-restriction fragment length polymorphism strategy and DNA sequencing. We also performed a meta-analysis of relevant studies, involving 1084 cases and 1721 controls, to place our findings in a broader context. No significant relationship was observed between the MMP-1 -1607 1G/2G alleles and genotypes and the risk of GC. There were significant differences in the genotypes and allele distributions of the -181 A/G polymorphism of the MMP-7 gene between cases and controls. The -181 A allele carriers had a significantly increased risk of GC compared with -181 G allele carriers (OR=3.051, 95% CI, 1.475-6.310, P=0.002), and the AA genotype of -181 A/G was associated with an increased risk of GC compared with the AG genotype (OR=3.189, 95% CI, 1.523-6.676, P=0.001). A meta-analysis of six studies also showed a significant risk of GC associated with MMP-7 polymorphism." @default.
- W2213462949 created "2016-06-24" @default.
- W2213462949 creator A5007320512 @default.
- W2213462949 creator A5022444278 @default.
- W2213462949 creator A5028963094 @default.
- W2213462949 creator A5029610764 @default.
- W2213462949 creator A5032784258 @default.
- W2213462949 creator A5040565453 @default.
- W2213462949 date "2013-07-09" @default.
- W2213462949 modified "2023-09-24" @default.
- W2213462949 title "Genetic polymorphisms in Matrix Metalloproteinases -1 and -7 and susceptibility to gastric cancer: an association study and meta-analysis." @default.
- W2213462949 cites W1553702758 @default.
- W2213462949 cites W1976153664 @default.
- W2213462949 cites W1977301930 @default.
- W2213462949 cites W1983922892 @default.
- W2213462949 cites W1994016632 @default.
- W2213462949 cites W2012440275 @default.
- W2213462949 cites W2025760013 @default.
- W2213462949 cites W2035669449 @default.
- W2213462949 cites W2040178251 @default.
- W2213462949 cites W2048713921 @default.
- W2213462949 cites W2077236909 @default.
- W2213462949 cites W2081172418 @default.
- W2213462949 cites W2092384895 @default.
- W2213462949 cites W2101364916 @default.
- W2213462949 cites W2120127537 @default.
- W2213462949 cites W2123356446 @default.
- W2213462949 cites W2125435699 @default.
- W2213462949 cites W2137060946 @default.
- W2213462949 cites W2150000105 @default.
- W2213462949 cites W2157823046 @default.
- W2213462949 cites W2237564743 @default.
- W2213462949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23893803" @default.
- W2213462949 hasPublicationYear "2013" @default.
- W2213462949 type Work @default.
- W2213462949 sameAs 2213462949 @default.
- W2213462949 citedByCount "8" @default.
- W2213462949 countsByYear W22134629492015 @default.
- W2213462949 countsByYear W22134629492017 @default.
- W2213462949 countsByYear W22134629492018 @default.
- W2213462949 countsByYear W22134629492019 @default.
- W2213462949 crossrefType "journal-article" @default.
- W2213462949 hasAuthorship W2213462949A5007320512 @default.
- W2213462949 hasAuthorship W2213462949A5022444278 @default.
- W2213462949 hasAuthorship W2213462949A5028963094 @default.
- W2213462949 hasAuthorship W2213462949A5029610764 @default.
- W2213462949 hasAuthorship W2213462949A5032784258 @default.
- W2213462949 hasAuthorship W2213462949A5040565453 @default.
- W2213462949 hasConcept C104317684 @default.
- W2213462949 hasConcept C109523444 @default.
- W2213462949 hasConcept C126322002 @default.
- W2213462949 hasConcept C135763542 @default.
- W2213462949 hasConcept C151730666 @default.
- W2213462949 hasConcept C153209595 @default.
- W2213462949 hasConcept C153911025 @default.
- W2213462949 hasConcept C180754005 @default.
- W2213462949 hasConcept C2779343474 @default.
- W2213462949 hasConcept C49105822 @default.
- W2213462949 hasConcept C54355233 @default.
- W2213462949 hasConcept C71924100 @default.
- W2213462949 hasConcept C86803240 @default.
- W2213462949 hasConcept C90924648 @default.
- W2213462949 hasConcept C95190672 @default.
- W2213462949 hasConceptScore W2213462949C104317684 @default.
- W2213462949 hasConceptScore W2213462949C109523444 @default.
- W2213462949 hasConceptScore W2213462949C126322002 @default.
- W2213462949 hasConceptScore W2213462949C135763542 @default.
- W2213462949 hasConceptScore W2213462949C151730666 @default.
- W2213462949 hasConceptScore W2213462949C153209595 @default.
- W2213462949 hasConceptScore W2213462949C153911025 @default.
- W2213462949 hasConceptScore W2213462949C180754005 @default.
- W2213462949 hasConceptScore W2213462949C2779343474 @default.
- W2213462949 hasConceptScore W2213462949C49105822 @default.
- W2213462949 hasConceptScore W2213462949C54355233 @default.
- W2213462949 hasConceptScore W2213462949C71924100 @default.
- W2213462949 hasConceptScore W2213462949C86803240 @default.
- W2213462949 hasConceptScore W2213462949C90924648 @default.
- W2213462949 hasConceptScore W2213462949C95190672 @default.
- W2213462949 hasIssue "3" @default.
- W2213462949 hasLocation W22134629491 @default.
- W2213462949 hasOpenAccess W2213462949 @default.
- W2213462949 hasPrimaryLocation W22134629491 @default.
- W2213462949 hasRelatedWork W1511048503 @default.
- W2213462949 hasRelatedWork W1992647879 @default.
- W2213462949 hasRelatedWork W2008843816 @default.
- W2213462949 hasRelatedWork W2027619390 @default.
- W2213462949 hasRelatedWork W2107074164 @default.
- W2213462949 hasRelatedWork W2359432862 @default.
- W2213462949 hasRelatedWork W2409745059 @default.
- W2213462949 hasRelatedWork W2883538728 @default.
- W2213462949 hasRelatedWork W3206047998 @default.
- W2213462949 hasRelatedWork W4239379028 @default.
- W2213462949 hasVolume "12" @default.
- W2213462949 isParatext "false" @default.
- W2213462949 isRetracted "false" @default.
- W2213462949 magId "2213462949" @default.
- W2213462949 workType "article" @default.