FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2213731036> ?p ?o ?g. }

• W2213731036 abstract "Despite pleiotropic immunomodulatory effects of apolipoprotein E (apoE) in vitro, its effects on the clinical course of experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS) are still controversial. As sex hormones modify immunomodulatory apoE functions, they may explain contentious findings. This study aimed to investigate sex-specific effects of apoE on disease course of EAE and MS. MOG35-55 induced EAE in female and male apoE-deficient mice was assessed clinically and histopathologically. apoE expression was investigated by qPCR. The association of the MS severity score (MSSS) and APOE rs429358 and rs7412 was assessed across 3237 MS patients using linear regression analyses. EAE disease course was slightly attenuated in male apoE-deficient (apoE −/− ) mice compared to wildtype mice (cumulative median score: apoE −/− = 2 [IQR 0.0–4.5]; wildtype = 4 [IQR 1.0–5.0]; n = 10 each group, p = 0.0002). In contrast, EAE was more severe in female apoE −/− mice compared to wildtype mice (cumulative median score: apoE −/− = 3 [IQR 2.0–4.5]; wildtype = 3 [IQR 0.0–4.0]; n = 10, p = 0.003). In wildtype animals, apoE expression during the chronic EAE phase was increased in both females and males (in comparison to naïve animals; p < 0.001). However, in MS, we did not observe a significant association between MSSS and rs429358 or rs7412, neither in the overall analyses nor upon stratification for sex. apoE exerts moderate sex-specific effects on EAE severity. However, the results in the apoE knock-out model are not comparable to effects of polymorphic variants in the human APOE gene, thus pinpointing the challenge of translating findings from the EAE model to the human disease." @default.
• W2213731036 created "2016-06-24" @default.
• W2213731036 creator A5002019832 @default.
• W2213731036 creator A5004136948 @default.
• W2213731036 creator A5005476990 @default.
• W2213731036 creator A5013771455 @default.
• W2213731036 creator A5014446359 @default.
• W2213731036 creator A5020099345 @default.
• W2213731036 creator A5021067270 @default.
• W2213731036 creator A5026430936 @default.
• W2213731036 creator A5027960258 @default.
• W2213731036 creator A5028410367 @default.
• W2213731036 creator A5029493363 @default.
• W2213731036 creator A5030054597 @default.
• W2213731036 creator A5033863056 @default.
• W2213731036 creator A5040106901 @default.
• W2213731036 creator A5042022671 @default.
• W2213731036 creator A5055426639 @default.
• W2213731036 creator A5055558719 @default.
• W2213731036 creator A5057709653 @default.
• W2213731036 creator A5057863942 @default.
• W2213731036 creator A5062220148 @default.
• W2213731036 creator A5062355834 @default.
• W2213731036 creator A5067185934 @default.
• W2213731036 creator A5068489993 @default.
• W2213731036 creator A5069481185 @default.
• W2213731036 creator A5080424404 @default.
• W2213731036 creator A5083000991 @default.
• W2213731036 date "2015-12-01" @default.
• W2213731036 modified "2023-10-09" @default.
• W2213731036 title "Investigation of sex-specific effects of apolipoprotein E on severity of EAE and MS" @default.
• W2213731036 cites W1528661679 @default.
• W2213731036 cites W1607206274 @default.
• W2213731036 cites W1876581925 @default.
• W2213731036 cites W1963963818 @default.
• W2213731036 cites W1978094617 @default.
• W2213731036 cites W1979485513 @default.
• W2213731036 cites W1980171878 @default.
• W2213731036 cites W1984737558 @default.
• W2213731036 cites W1985777017 @default.
• W2213731036 cites W1998009350 @default.
• W2213731036 cites W2004181696 @default.
• W2213731036 cites W2008256259 @default.
• W2213731036 cites W2012347097 @default.
• W2213731036 cites W2027639859 @default.
• W2213731036 cites W2037389395 @default.
• W2213731036 cites W2038153181 @default.
• W2213731036 cites W2040358504 @default.
• W2213731036 cites W2040547343 @default.
• W2213731036 cites W2041090343 @default.
• W2213731036 cites W2045663319 @default.
• W2213731036 cites W2061278328 @default.
• W2213731036 cites W2084196117 @default.
• W2213731036 cites W2086881464 @default.
• W2213731036 cites W2091228274 @default.
• W2213731036 cites W2103502637 @default.
• W2213731036 cites W2112165124 @default.
• W2213731036 cites W2126718294 @default.
• W2213731036 cites W2132691011 @default.
• W2213731036 cites W2139344244 @default.
• W2213731036 cites W2147872051 @default.
• W2213731036 cites W2154431665 @default.
• W2213731036 cites W2155397417 @default.
• W2213731036 cites W2159203244 @default.
• W2213731036 cites W2159285109 @default.
• W2213731036 cites W2161633633 @default.
• W2213731036 cites W4210821588 @default.
• W2213731036 cites W4253839249 @default.
• W2213731036 doi "https://doi.org/10.1186/s12974-015-0429-y" @default.
• W2213731036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4681148" @default.
• W2213731036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26669675" @default.
• W2213731036 hasPublicationYear "2015" @default.
• W2213731036 type Work @default.
• W2213731036 sameAs 2213731036 @default.
• W2213731036 citedByCount "10" @default.
• W2213731036 countsByYear W22137310362017 @default.
• W2213731036 countsByYear W22137310362018 @default.
• W2213731036 countsByYear W22137310362019 @default.
• W2213731036 countsByYear W22137310362021 @default.
• W2213731036 countsByYear W22137310362022 @default.
• W2213731036 crossrefType "journal-article" @default.
• W2213731036 hasAuthorship W2213731036A5002019832 @default.
• W2213731036 hasAuthorship W2213731036A5004136948 @default.
• W2213731036 hasAuthorship W2213731036A5005476990 @default.
• W2213731036 hasAuthorship W2213731036A5013771455 @default.
• W2213731036 hasAuthorship W2213731036A5014446359 @default.
• W2213731036 hasAuthorship W2213731036A5020099345 @default.
• W2213731036 hasAuthorship W2213731036A5021067270 @default.
• W2213731036 hasAuthorship W2213731036A5026430936 @default.
• W2213731036 hasAuthorship W2213731036A5027960258 @default.
• W2213731036 hasAuthorship W2213731036A5028410367 @default.
• W2213731036 hasAuthorship W2213731036A5029493363 @default.
• W2213731036 hasAuthorship W2213731036A5030054597 @default.
• W2213731036 hasAuthorship W2213731036A5033863056 @default.
• W2213731036 hasAuthorship W2213731036A5040106901 @default.
• W2213731036 hasAuthorship W2213731036A5042022671 @default.
• W2213731036 hasAuthorship W2213731036A5055426639 @default.
• W2213731036 hasAuthorship W2213731036A5055558719 @default.
• W2213731036 hasAuthorship W2213731036A5057709653 @default.
• W2213731036 hasAuthorship W2213731036A5057863942 @default.

• next