Matches in SemOpenAlex for { <https://semopenalex.org/work/W2214000001> ?p ?o ?g. }
- W2214000001 endingPage "219" @default.
- W2214000001 startingPage "213" @default.
- W2214000001 abstract "Galectins (Gals) have emerged as potent immunoregulatory molecules that control chronic inflammation through distinct mechanisms. Gal-8, a tandem-repeat type Gal with unique preference for α2,3-sialylated glycans, is ubiquitously expressed, but little is known about its role in T-cell differentiation. Here we report that Gal-8 promotes the polyclonal differentiation of primary mouse regulatory T (Treg) cells in vitro. We further show that Gal-8 also facilitates antigen-specific differentiation of Treg cells, and that Treg cells polarized in the presence of Gal-8 express cytotoxic T-lymphocyte antigen-4 and interleukin (IL)-10 at a higher frequency than control Treg cells, and efficiently inhibit proliferation of activated T-cells in vitro. Investigation of the mechanism by which Gal-8 promotes Treg conversion revealed that Gal-8 activates transforming growth factor-β signaling and promotes sustained IL-2R signaling. Taken together, these data suggest that Gal-8 promotes the differentiation of highly suppressive Treg cells, which has implications for the treatment of inflammatory and autoimmune diseases." @default.
- W2214000001 created "2016-06-24" @default.
- W2214000001 creator A5005626770 @default.
- W2214000001 creator A5023655520 @default.
- W2214000001 creator A5024226262 @default.
- W2214000001 creator A5029103579 @default.
- W2214000001 creator A5042209857 @default.
- W2214000001 date "2015-08-18" @default.
- W2214000001 modified "2023-10-18" @default.
- W2214000001 title "Galectin‐8 promotes regulatory T‐cell differentiation by modulating IL‐2 and TGFβ signaling" @default.
- W2214000001 cites W1541574343 @default.
- W2214000001 cites W1583391226 @default.
- W2214000001 cites W1945990857 @default.
- W2214000001 cites W1980035883 @default.
- W2214000001 cites W1985997449 @default.
- W2214000001 cites W2004619659 @default.
- W2214000001 cites W2010943289 @default.
- W2214000001 cites W2022099686 @default.
- W2214000001 cites W2024722792 @default.
- W2214000001 cites W2030284768 @default.
- W2214000001 cites W2041659209 @default.
- W2214000001 cites W2064003371 @default.
- W2214000001 cites W2067074405 @default.
- W2214000001 cites W2070631889 @default.
- W2214000001 cites W2071071778 @default.
- W2214000001 cites W2072772016 @default.
- W2214000001 cites W2084152213 @default.
- W2214000001 cites W2088373848 @default.
- W2214000001 cites W2090478907 @default.
- W2214000001 cites W2096267364 @default.
- W2214000001 cites W2102538857 @default.
- W2214000001 cites W2113071839 @default.
- W2214000001 cites W2117156688 @default.
- W2214000001 cites W2118131724 @default.
- W2214000001 cites W2131986593 @default.
- W2214000001 cites W2141649011 @default.
- W2214000001 cites W2141767234 @default.
- W2214000001 cites W2144258105 @default.
- W2214000001 cites W2145533331 @default.
- W2214000001 cites W2146796201 @default.
- W2214000001 cites W2149915530 @default.
- W2214000001 cites W2153919683 @default.
- W2214000001 cites W2160023163 @default.
- W2214000001 cites W2160726446 @default.
- W2214000001 cites W4235086811 @default.
- W2214000001 doi "https://doi.org/10.1038/icb.2015.72" @default.
- W2214000001 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4747822" @default.
- W2214000001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26857020" @default.
- W2214000001 hasPublicationYear "2015" @default.
- W2214000001 type Work @default.
- W2214000001 sameAs 2214000001 @default.
- W2214000001 citedByCount "33" @default.
- W2214000001 countsByYear W22140000012016 @default.
- W2214000001 countsByYear W22140000012017 @default.
- W2214000001 countsByYear W22140000012018 @default.
- W2214000001 countsByYear W22140000012019 @default.
- W2214000001 countsByYear W22140000012020 @default.
- W2214000001 countsByYear W22140000012021 @default.
- W2214000001 countsByYear W22140000012022 @default.
- W2214000001 countsByYear W22140000012023 @default.
- W2214000001 crossrefType "journal-article" @default.
- W2214000001 hasAuthorship W2214000001A5005626770 @default.
- W2214000001 hasAuthorship W2214000001A5023655520 @default.
- W2214000001 hasAuthorship W2214000001A5024226262 @default.
- W2214000001 hasAuthorship W2214000001A5029103579 @default.
- W2214000001 hasAuthorship W2214000001A5042209857 @default.
- W2214000001 hasBestOaLocation W22140000012 @default.
- W2214000001 hasConcept C104317684 @default.
- W2214000001 hasConcept C118131993 @default.
- W2214000001 hasConcept C148738053 @default.
- W2214000001 hasConcept C154317977 @default.
- W2214000001 hasConcept C156293190 @default.
- W2214000001 hasConcept C202751555 @default.
- W2214000001 hasConcept C203014093 @default.
- W2214000001 hasConcept C55493867 @default.
- W2214000001 hasConcept C86803240 @default.
- W2214000001 hasConcept C95444343 @default.
- W2214000001 hasConceptScore W2214000001C104317684 @default.
- W2214000001 hasConceptScore W2214000001C118131993 @default.
- W2214000001 hasConceptScore W2214000001C148738053 @default.
- W2214000001 hasConceptScore W2214000001C154317977 @default.
- W2214000001 hasConceptScore W2214000001C156293190 @default.
- W2214000001 hasConceptScore W2214000001C202751555 @default.
- W2214000001 hasConceptScore W2214000001C203014093 @default.
- W2214000001 hasConceptScore W2214000001C55493867 @default.
- W2214000001 hasConceptScore W2214000001C86803240 @default.
- W2214000001 hasConceptScore W2214000001C95444343 @default.
- W2214000001 hasFunder F4320337350 @default.
- W2214000001 hasIssue "2" @default.
- W2214000001 hasLocation W22140000011 @default.
- W2214000001 hasLocation W22140000012 @default.
- W2214000001 hasLocation W22140000013 @default.
- W2214000001 hasLocation W22140000014 @default.
- W2214000001 hasLocation W22140000015 @default.
- W2214000001 hasOpenAccess W2214000001 @default.
- W2214000001 hasPrimaryLocation W22140000011 @default.
- W2214000001 hasRelatedWork W147664338 @default.
- W2214000001 hasRelatedWork W1543370363 @default.