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• W2214077649 endingPage "138" @default.
• W2214077649 startingPage "101" @default.
• W2214077649 abstract "Publisher Summary The heterogeneity of receptors mediating 5-HT responses was apparent long before their definitive identification using cloning techniques, largely due to radioligand binding studies. Hence, as early as 1979, 5-HT recognition sites were subdivided into two classes. Those that had a high affinity for agonists and were labeled with [3H]5-HT were termed “5-HT 1 binding sites” and those that displayed a high affinity for antagonists and were labeled with [aH]spiperone were called “5-HT 2 binding sites.” In 1981, Pedigo demonstrated that spiperone displaced [aH]5-HT in a complex manner; hence, the 5-HT 1 class comprised at least two subgroups. The component having a high affinity for spiperone was called a “5-HT 1A recognition site” (labeled with [∼H]8-OH-DPAT) and the remaining component the “5-HT 1B binding site” (subsequently labeled with [125I]ICYP (iodocyanopindolol) in the presence of isoprenaline)." @default.
• W2214077649 created "2016-06-24" @default.
• W2214077649 creator A5022674193 @default.
• W2214077649 creator A5063815988 @default.
• W2214077649 creator A5087047459 @default.
• W2214077649 date "1997-01-01" @default.
• W2214077649 modified "2023-09-23" @default.
• W2214077649 title "5-HT1D receptors" @default.
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