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- W2214092894 abstract "Purified rat liver aryl sulfotransferase Ⅳ (AST Ⅳ) was found to be inhibited in vitro by zinc, copper, cadmium and terbium, Among these four elements, zinc, copper and cadmium were all strongly inhibitory to the AST Ⅳ activity at very low concentratiom (2.5 ㎛ to 0.025 ㎛). In rat liver cytosol, zinc, copper and cadmium at 25 ㎛ to 0.025 ㎛ also decreased the AST Ⅳ activity to 50% of the controls. In order to assess the possible effects of these metals on the AST Ⅳ activity recovery pattern in vivo, studies on the relationship between these minerals and dietary 2-acetylaminofluorene were conducted Total of forty rats were fed one of five diets for 6 weeks: diet 1, Control diet phis 2-acetlyaminofluorene (0.05%); diet 2, zinc-deficient diet plus 2-acetlyaminofluorene; diet 3, zinc-supplement diet plus 2-acetylaminofluorene; diet 4, copper-supplement diet plus 2-acetiyaminofluorene; diet 5, cadmium-supplement diet plus 2-acetylaminofluorene. Half of the rats from each diet were changed to individual diet after 3 weeks of 2-acetylamnofluorene feeding. Placement of rats on the control diet following one cycle of 2-acetylaminofluorene feeding of 3 weeks without 2-acetylaminofluorene resulted in nearly full recovery of AST Ⅳ activity within 3 or 4 weeks. However, the rats fed diets that supplemented with zinc, copper or cadmium without 2-acetylaminofluorene showed a new pattern of lowered AST Ⅳ activity as early as the first cycle. Also, lowering in cytosolic AST Ⅳ contents was appeared in the Iivers from the rats, following one cycle of 2-acetlyaminofluorene feeding of 3 weeks, fed one of the diets that supplemented with copper, cadmium or zinc without 2-acetylaminofluorene for ensuing 3 weeks." @default.
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- W2214092894 date "2006-02-01" @default.
- W2214092894 modified "2023-09-24" @default.
- W2214092894 title "Effects of Copper, Zinc and Cadmium on the Recovery Pattern of Aryl Sulfotransferase IV Activity in Rats fed 2-Acetylaminofluorene Diet" @default.
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